Effects of ethanolic leaf extract of Psidium guajava Linn. on L-arginine induced obsessive compulsive disorder in mice
Journal Title: Scholars Academic Journal of Pharmacy - Year 2015, Vol 4, Issue 3
Abstract
Obsessive compulsive disorder (OCD) is a high-prevalence psychiatric disorder affecting 2–5% of the population. It is a type of anxiety disorder in which people suffer from recurrent, unwanted thoughts or ideas (obsessions), engage in repetitive, irrational behaviors or mental acts (compulsions) or both. Although its pathophysiology remains unclear, current evidence implicates contributions of the serotonergic and dopaminergic neurotransmitter systems and a neural circuitry that includes the orbitofrontal cortex, the thalamus and the striatum. In this present research work the pharmacological effect of ethanolic extract of Psidium guajava Linn.(EEPG) against L-arginine induced obsessions were evaluated along with in-vitro studies like estimation of serotonin and dopamine. From the results we found that the EEPG shown significant (p<0.05 - p<0.01) improvement in behavioral parameters viz. marble burying behavior, locomotion and memory retention. It is also identified that the EEPG treated groups had shown the significant (p<0.01 and p<0.05) increase in levels of dopamine and serotonin which may be responsible for behavioral functions. Keywords: OCD, Marble burying behavior, Psidium guajava and Anxiety.
Authors and Affiliations
Krishna Mohan Chinnala, Swetha Jukanti, Madhan Mohan Elsani
Keywords
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