Effects of Melatonin at Different Doses on Experimental Epilepsy Model Induced By Pentylenetetrazole
Journal Title: Meandros Medical and Dental Journal - Year 2021, Vol 22, Issue 2
Abstract
Objective: This study aimed to evaluate the effect of melatonin (MEL) treatment on rats with experimental epilepsy induced by pentylenetetrazole (PTZ). Changes in the control, epilepsy and two treatment groups (25 mg/kg and 100 mg/kg) were monitored as intragroup and intergroup changes. Materials and Methods: Forty male Wistar albino rats (12-14 weeks old) were divided into control, PTZ, MEL25 and MEL100 groups, with 10 rats in each group. Only solvent was injected in the control group, and PTZ at a dose of 35 mg/kg was administered intraperitoneal 12 times in a total of 23 days in the PTZ group. MEL25 and 100 mg/kg were administered in the MEL25 and MEL100 groups, respectively. Parameters tested during and after the experiment were behavioural tests (elevated plus maze), biochemical tests in brain tissue [after decapitation; malondialdehyde (MDA), catalase (CAT), superoxide dismutase (SOD), total antioxidant status (TAS) and total oxidant status (TOS)] and epileptic seizure severity scale scores (every injection day). Results:Significant differences were observed among the epilepsy, control and treatment groups, except for the hiding times, seizure scores and biochemical tests (p<0.05). As a result of biochemical tests applied to the homogenised brain tissue after decapitation, dose-dependent results were found to be related to the different doses of MEL applied in MDA, CAT, SOD, TAS and TOS levels (p<0.05). Conclusion: In this study, MEL showed a protective and healing role against physiological changes caused by experimental epilepsy, through its capacity to reduce oxidative damage and increase antioxidant potency.
Authors and Affiliations
Ferhat Şirinyıldız, Rauf Onur Ek
Keywords
Related Articles
- EP ID EP694417
- DOI 10.4274/meandros.galenos.2021.49358
- Views 129
- Downloads 0
Evaluation of Knowledge, Attitude and Behaviour on Oral Health Through COVID-19 Pandemic
Objective: This research is aimed at determining the changes in individuals’ knowledge, attitudes and behaviours regarding oral health in terms of nutritional habits, daily oral care and the provision of dental services...
The Effect of Different Irrigation Solutions on the Accuracy of Two Electronic Apex Locators in Locating Artificial Root Perforations
Objective: This study aimed to assess the accuracy of the Raypex 6 (VDW GmbH, Munich, Germany) and Root ZX mini (J. Morita Corp., Tokyo, Japan) electronic apex locators (EALs) with regard to detecting root perforations i...
Effect of Grape Seed Extract on Bone Formation in The Expanded Interpremaxillary Suture
Objective: Widening the inter-maxillary suture is a preferred procedure in orthodontics. However, relapse can occur in some patients after maxillary expansion therapy. This study aimed to increase bone formation in the i...
The Effects of Vitamin D Level on Bone Lesions and Prognostic Factors in Multiple Myeloma
Objective: Several studies have found that low vitamin D levels are associated with an increased risk of hematologic malignancies and a poor prognosis. In this study, we investigated the relationship between 25-hydroxyvi...
Inherited Rare Factor Deficiencies: Single-centre Experience
Objective: Bleeding is one of the most important problems in humans. Absence, deficiency or dysfunctions of protein factors in the coagulation system can cause prolonged bleeding, morbidity or mortality. Although factor...