Effects of midazolam and buspirone on in vivo concentration of amino acids and monoamine metabolites in the rat hippocampus.
Journal Title: Pharmacological Reports - Year 2008, Vol 60, Issue 2
Abstract
The effects of anxiolytic doses of buspirone and midazolam (established in the conditioned fear test) on extracellular concentrations of glutamate, GABA, serotonin and dopamine metabolites in the hippocampus were examined in vivo, in freely moving rats. Buspirone at a dose of 1.5 mg/kg ip disinhibited rat behavior in the conditioned fear test (a freezing response) much stronger than 1.0 mg/kg of midazolam. Both drugs enhanced the local concentration of glutamate to the similar extent, and decreased the concentration of 5-hydroxyindole acetic acid (5-HIAA). Buspirone increased also the extracellular levels of dopamine metabolites: homovanillic acid (HVA) and 3,4-dihydroxyphenylacetic acid (DOPAC). It is suggested that the changes in hippocampal glutamate probably are not directly associated with modification of rat emotional behavior after benzodiazepines and azapirones. The present results provide more arguments for the role of hippocampal 5-HT in the effects of anxiolytic drugs.
Authors and Affiliations
Aleksandra Wisłowska-Stanek, Adam Hamed, Małgorzata Lehner, Andrzej Bidziński, Danuta Turzyńska, Alicja Sobolewska, Jerzy Walkowiak
Keywords
Related Articles
- EP ID EP144536
- DOI -
- Views 112
- Downloads 0
Effectiveness of lipid-lowering therapy with statins for secondary prevention of atherosclerosis - guidelines vs. reality.
Background: The aim of the study was to analyze the effectiveness of lipid-lowering therapy and therapeutic decisions made by physicians for patients not achieving LDL targets. Methods: 11,768 patients undergoing therapy...
Glycoprotein (116 kD) isolated from Ulmus davidiana Nakai protects from injury of 12-O-tetradecanoylphorbol 13-acetate (TPA)-treated BNL CL.2 cells.
Ulmus davidiana Nakai (UDN) has been used for a long time to cure inflammation in oriental medicine. To evaluate the cytoprotective effects of the UDN glycoprotein, we measured cytotoxicity, the level of intracellular re...
Attenuation of stress-induced behavioral deficits by lithium administration via serotonin metabolism.
Background: Although the mood stabilizing role of lithium is well established and the cognitive effects of lithium are also best demonstrated, but its primary effect on neurochemical profile and behaviors under stress re...
Influence of chronic stress on brain corticosteroid receptors and HPA axis activity.
Background: Disruption of the glucocorticoid negative feedback system evoked in animals by chronic stress can be induced by downregulation of glucocorticoid receptors (GRs) in several brain regions. In the present study,...
Ganoderic acid T inhibits tumor invasion in vitro and in vivo through inhibition of MMP expression.
The traditional Chinese medicinal mushroom, Ganoderma lucidum, has been used in Asia for several thousand years for the prevention and treatment of a variety of diseases, including cancer. In previous work, we purified g...