Effects of photodynamic therapy with Ranibizumab on visual acuity and postoperative complications in patients with PCV complicated with vitreous hemorrhage
Journal Title: Guoji Yanke Zazhi - Year 2018, Vol 18, Issue 12
Abstract
AIM:To explore the photodynamic therapy(PDT)combined with intravitreal injection of Ranibizumab(IVR)on visual acuity, central macular thickness(CMT)and postoperative complications in the treatment of polypoidal choroidal vasculopathy(PCV)complicated with vitreous hemorrhage(VH). <p>METHODS: Totally 71 cases of patients(71 eyes)with PCV complicated with VH were divided into two groups according to the treatment methods. And observation group(<i>n</i>=43)was given PDT with IVR after vitrectomy, and control group(<i>n</i>=28)was only given IVR adjuvant treatment. The best corrected visual acuity(BCVA), CMT and postoperative complications were followed up at the 1<sup>st</sup>, 3<sup>rd</sup> and 6<sup>th</sup> month after treatment. <p>RESULTS: After treatment, the BCVA in the two groups was gradually improved while the CMT was gradually decreased with time, and the difference within-groups at different times was statistically significant(<i>P</i><0.05), and there were statistically significant differences in BCVA and CMT between the two groups at the same time after treatment(<i>P</i><0.05). After treatment, the closure of CNV lesion in observation group was significantly better than that in control group(<i>P</i><0.05), and the complete closure rate was higher than that in control group(<i>χ<sup>2</sup></i>=4.508, <i>P</i><0.05). There was 6 cases(14%)of related complications in observation group after treatment and 5 cases(18%)in control group, and there was no statistically significant difference between the two groups(<i>P</i>>0.05). <p>CONCLUSION: PDT combined with IVR for patients with PCV and VH after vitrectomy is beneficial to promote the absorption of vascular exudate and the elimination of polypoid lesions, thus reducing macular edema, improving the visual acuity and reducing postoperative complications. And its clinical efficacy and safety are worthy of recognition.
Authors and Affiliations
Jing Yan
Keywords
Related Articles
- EP ID EP501592
- DOI 10.3980/j.issn.1672-5123.2018.12.20
- Views 149
- Downloads 0
Efficacy of 23G minimally invasive system combined with phacoemulsification for cataract complicated with vitreoretinopathy
AIM: To observe the efficacy of 23G minimally invasive system combined with phacoemulsification in the treatment of cataract complicated with vitreoretinopathy. <p>METHODS: Totally 96 cases(103 eyes)of patients with cata...
Clinical study of intraocular pressure and retinal thickness affected by residual triamcinolone acetonide after vitrectomy
AIM: To study the effect of residual triamcinolone acetonide(TA)to intraocular pressure(IOP)and retinal thickness in patients after vitrectomy. <p>METHODS: Retrospective study. The medical data of 83 patients(83 eyes)aft...
Comparison on biomechanical stability between femtosecond laser assisted LASIK and LASEK with ocular response analyzer
AIM: To compare the difference of biomechanical stability after a femtosecond laser-assisted <i>in situ</i> keratomileusis(FS-LASIK)and laser-assisted subepithelial keratomileusis(LASEK)by ocular response analyzer(ORA)....
Identification of pathogenic nonsporulating molds in eyes by internal transcribed spacer sequences alignment
AIM: To identify the species and genus of pathogenic nonsporulating molds(NSM)by internal transcribed spacer(ITS)sequences alignment, and reveal the biodiversity of NSM in Hainan Island with tropical climate. <p>METHODS:...
Effect of diabetes duration on ocular surface of cataract patients with diabetes mellitus
AIM: To observe the effects of different duration of diabetes on dry eye and ocular surface before cataract surgery. <p>METHODS: The patients with diabetes and cataract were included from March to August in 2018. Accordi...