Effects of sunlight exposure vs. commercial vitamin D supplementation on the bone health of vitamin D deficient rats
Journal Title: International Journal of Life Science - Year 2016, Vol 4, Issue 1
Abstract
This study compared sun exposure with commercial vitamin D3 supplementation in restoring bone health in a vitamin D deficient rat model. 35 healthy weaned male albino rats were divided into two groups. Vitamin D deficient rats (n=21) were subdivided into: an Sd group (n=7) that was directly exposed to sun-light, a Tt group (n=7) that was treated with commercial vitamin D3 with oil, and a Ct group (n=7) that was treated with canola oil without vitamin D. Normal diet fed rats were subdivided into: a Cs group (n=7) that was exposed to sunlight and fed a normal vitamin D chow and a control (C) group(n=7). Plasma 25 hydroxy vitamin D3, parathyroid hormone, calcium, phosphorus levels and the enzymatic activity of alkaline phosphatase were estimated and femur bones were used to prepare histopathological sections. The sun-exposed groups showed a significant reduction in levels of parathyroid hormone (67.69±13.18 vs 86.05±9.67 pg/mL, P < 0.05) in addition to an improvement of osteoid area and a reduction of trabecular separation in the bone sections. In a conclusion, sun-exposure have a more positive effect on bone structure and hormones that control bone mass rather than normalization of vitamin D. Key words:
Authors and Affiliations
Ali Abulmeaty Mahmoud Mustafa
Keywords
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