Effects of the Aqueous and Methanol Extracts of Alchornea Laxiflora in Rodent Models of Experimental Psychosis
Journal Title: IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS) - Year 2018, Vol 13, Issue 4
Abstract
The study investigated the median lethal dose and the effects of the aqueous and methanol extracts of Alchornea laxiflora in two mouse models of experimental psychosis, the apomorphine-induced climbing behavior and apomorphine-induced stereotypy tests. This was with a view to providing information on the acute toxicity and the antipsychotic potential of the plant extracts. Mice of both sexes (n=6) weighing 18 – 22 g were used for the study, which were randomized into control and test groups, which summed up to seven (7) groups. The control group (1) received 10 % Tween 80 (vehicle), 0.1 ml/10 g mouse while the test groups (II, III, IV, V, VI) were administered graded doses (100, 200, 400, 800, 1600 mg/kg, p.o.) of the extracts. The standard group (VII) received a standard drug, Chlorpromazine (2 mg/kg, i.p.). The animals were observed for climbing and stereotypic behaviours in a wire mesh and observation cage respectively. They were individually scored after observation for 2 min at 10, 20, 30 and 45 min intervals post intra-peritoneal and oral administrations of vehicle, extracts or drugs. The LD50 for the aqueous and methanol extracts of A. laxiflora in the oral route was > 1600 mg/kg respectively, and found to be safe in animals. However, the LD50 (i.p.), was found to be 400 mg/kg for the methanol extract, which was relatively toxic, and > 1600 mg/kg for the aqueous extract. The results showed that A. laxiflora produced significant (P = 0.000) attenuation of apomorphine-induced climbing and apomorphine-induced stereotypic behaviours. The study, therefore, concluded that A. laxiflora possesses antipsychotic activity in mice.
Authors and Affiliations
C. N. S. Nwonu, O. R. Ilesanmi, J. M. Agbedahunsi, P. C. Nwonu
Keywords
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