Effects of Tramadol on Fertility Hormones (Follicle Stimulating Hormone, Leutinizing Hormone, Prolactin, Testosterone, Estrogen and β-HCG) in Laboratory Rabbits

Journal Title: Journal of Advances in Medicine and Medical Research - Year 2016, Vol 14, Issue 8

Abstract

Drug abuse in Nigeria has been indicated to be on the rise in recent years. The use of hard drugs and misuse of prescription drugs for nonmedical purposes cuts across all strata, especially the youths. Tramadol (2[(Dimethylamin) methyl]-1-(3-methoxyphenyl)cyclohexanol) is known for its analgesic potentials. This potent opioid pain killer is misused by Nigerian youths, owing to its suspicion as sexual performance drug. This study therefore is aimed at determining the effect of tramadol on hormone levels its improved libido properties and possibly fertility. Twenty seven (27) European rabbits weighing 1.0 to 2.0 kg were used. Animals were divided into four major groups consisting of male and female control, and male and female tramadol treated groups. Treated groups were further divided into oral and intramuscular (IM) administered groups. Oral groups were administered 25 mg/kg b.w. of tramadol per day while the IM groups received 15 mg/kg b.w. per day over a period of thirty days. Blood samples were collected at the end of the experiment for progesterone, testosterone, estrogen (E2), luteinizing hormone, follicle stimulating hormone (FSH), β-human chorionic gonadotropin and prolactin estimation. Tramadol treated groups were compared with control groups at the end of the study, as well as within group comparison was done. From the results, FSH was found to be significantly reduced (p<0.05) while LH increased significantly (p<0.05). A decrease was observed for testosterone (p<0.001), and estrogen, FSH, progesterone also decreased (p<0.05). Significant changes weren’t observed when IM groups were compared with oral groups. This study does not support an improvement of libido by tramadol, though its possible usefulness in the treatment of premature ejaculation may have been established, but its capabilities to induce male and female infertility is still in doubt.

Authors and Affiliations

H. B. Osadolor, J. A. Omo-Erhabor

Keywords

Related Articles

Eight Months vs Six Months Anti-TB Regimen in the Treatment of Newly Diagnosed Pulmonary Tuberculosis Patients in Nigeria

Background: The eight month’s treatment regimen (2RHZE/6EH) was used by the Nigerian National TB and Leprosy Control Programme for the management of tuberculosis cases since 2003 when they commenced operation until Octob...

New Insight into the Mechanisms of the Anti-hyperglycemic Action of Metformin

Although metformin is currently one of the most frequently prescribed drugs for the treatment of type 2 diabetes, the precise mechanism of its molecular action is not fully understood. Metformin induces mild and transien...

Overview of Blunt Chest Injury with Multiple Rib Fractures

Introduction: Thoracic trauma leading to multiple fractured ribs (MFR) remains common. The significant chest pain of multiple rib fractures can be difficult to manage and can lead to decreased pulmonary function, increas...

Antispermatogenic Activity of Aspilia africana Methanol Leaf Extract in Male Wistar Rats

Aims: This study was carried out to investigate the effect of Aspilia africana on the reproductive activity of male Wistar rats. Place and Duration of Study: The research was carried out in the Department of Human Anatom...

Monomelic Amyotrophy after Permethrin Poisoning

Monomelic amyotrophy (MMA) known as Hirayama disease (HD). The first report appeared in 1959 when Hirayama described 12 patients [1] then, a large group of patients was found from Japan [2,3]. MMA from South India was a...

Download PDF file
  • EP ID EP340547
  • DOI 10.9734/BJMMR/2016/24620
  • Views 86
  • Downloads 0

How To Cite

H. B. Osadolor, J. A. Omo-Erhabor (2016). Effects of Tramadol on Fertility Hormones (Follicle Stimulating Hormone, Leutinizing Hormone, Prolactin, Testosterone, Estrogen and β-HCG) in Laboratory Rabbits. Journal of Advances in Medicine and Medical Research, 14(8), 1-11. https://www.europub.co.uk/articles/-A-340547