Effects of Tranexamic Acid on Perioperative Blood Loss Associated with Total Knee Arthroplasty: A Randomized Double Blinded Prospective Study
Journal Title: International Journal of Medical Research Professionals - Year 2017, Vol 3, Issue 2
Abstract
Introduction: Total knee arthroplasty is usually associated with minimal intra-operative, but extensive postoperative blood loss, also because of the application of pneumatic tourniquet application there are theoretical risk of thrombotic complications. In this prospective randomized double blinded study we try to find out effect of tranexamic acid on hemostasis, bleeding and thrombotic incidences. Materials and Methods: 30 patients were allocated randomly to receive either 15mg/kg tranexamic acid or equal volume of placebo a few min before tourniquet deflation. Results: Mean blood loss during surgery was 659 (285) ml in the tranexamic acid group, and 1245 (623) ml in the control group (p<0.001). In the recovery room, tranexamic acid group lost 131(98) ml, and the control group lost 645 (300) ml (p<0.001), whereas in the ward tranexamic acid group lost 295 (220) ml, and the control group lost 600 (275) ml p<0.01). Conclusion: We found that there was less blood loss in the tranexamic acid group, during total knee arthroplasty with pneumatic tourniquet.
Authors and Affiliations
Lalit Kumar, Simple Chahar
Keywords
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- EP ID EP543761
- DOI 10.21276/ijmrp.2017.3.2.020
- Views 66
- Downloads 0
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