Efficacy and Safety of a Combination of Paracetamol, Levocetirizine and Phenylephrine in the symptomatic treatment of Common Cold and Allergic Rhinitis in Children: Phase IV Clinical Study

Journal Title: Journal of Medical Science And clinical Research - Year 2017, Vol 5, Issue 3

Abstract

Introduction –It is the most frequently encountered self-limiting viral respiratory diseases. Common cold has a greater adverse impact on, absenteeism, productivity and daily life so symptomatic therapy to treat the symptoms is often employed. A FDC of Paracetamol, an antipyretic, Phenylephrine, a nasal decongestant and Levocetirizine, an anti-histaminic is popular in the treatment of Common Cold and Allergic Rhinitis in adults. This Phase IV study appraised the efficacy and safety of a combination of Paracetamol, Phenylephrine and Levocetirizine in treatment of common cold. Methodology–Of 185 enrolled, 156 patients completed the study. Safety assessment was made by inspecting the adverse events during trial. Efficacy assessment was made by decrementing in TSS and four point Likerttype scales. Results– Reduction in TSS from 5.05 (baseline) to 2.58 (day 3) and 0.61(day 5). One point reduction in Likert-type symptom scale from Moderate to Mild took just 3 days. Nearly all the patients had >50% reduction in symptom score at all visit and majority of patients had complete relief from the symptom. 20 episodes of adverse events occurred and were of mild intensity. Conclusion – A fixed-dose combination of Paracetamol, Phenylephrine and Levocetirizine is safe and effective in the treatment of Common Cold and Allergic Rhinitis in children.

Authors and Affiliations

Dr. Mayuresh Kiran

Keywords

Related Articles

Use of Immunomarkers D2-40 and CD31 in Detection of Lymphovascular Invasion in Breast Carcinoma

Breast cancer is a major health problem in the world. It is a disease with significant morbidity and mortality. Metastasis and recurrence are the main causes of mortality in breast carcinoma. Lymphovascular invasion is a...

Simple Renal Cyst: An Independent Risk Factor of Hypertension

Objective/Aim: The detection of asymptomatic renal cysts is increasing with advancement of imagining techniques and availability. The aim of our study was to evaluate the presence of simple cysts with prehypertension and...

Disseminated Intravascular Coagulation: As Presenting Feature in Patients with Systemic Lupus Erythematosus - Two Case Reports

There are different types of initial manifestation of systemic lupus erythematosus (SLE) like rash, oral ulcers, joint pain, anaemia and repeated abortions1,2,3 but presenting with fever altered sensorium4,5, hepatopathy...

Teachers Physical Exposure Grading in Percentile Scale: Development and Assessment of Reliability

Background and Objectives: Work is essential in the lives of men and women; Although various scales for measuring the Physical exposure of most type of workers like commuter and aeromechanics and many more have already b...

Combined Therapeutic Effects of Arsenic Trioxide and Poly (Adp-Ribose) Polymerase Inhibitor on Chronic Myeloid Leukaemia Cell Line

Chronic myeloid leukaemia (CML) is a clonal myeloproliferative disorder that takes its origin from haematopoietic pluripotent stem cells and the difficulty in its treatment has been well documented. Arsenic trioxide (ATO...

Download PDF file
  • EP ID EP281342
  • DOI -
  • Views 86
  • Downloads 0

How To Cite

Dr. Mayuresh Kiran (2017). Efficacy and Safety of a Combination of Paracetamol, Levocetirizine and Phenylephrine in the symptomatic treatment of Common Cold and Allergic Rhinitis in Children: Phase IV Clinical Study. Journal of Medical Science And clinical Research, 5(3), 19524-19530. https://www.europub.co.uk/articles/-A-281342