Efficacy and Safety of a Combination of Paracetamol, Levocetirizine and Phenylephrine in the symptomatic treatment of Common Cold and Allergic Rhinitis in Children: Phase IV Clinical Study
Journal Title: Journal of Medical Science And clinical Research - Year 2017, Vol 5, Issue 3
Abstract
Introduction –It is the most frequently encountered self-limiting viral respiratory diseases. Common cold has a greater adverse impact on, absenteeism, productivity and daily life so symptomatic therapy to treat the symptoms is often employed. A FDC of Paracetamol, an antipyretic, Phenylephrine, a nasal decongestant and Levocetirizine, an anti-histaminic is popular in the treatment of Common Cold and Allergic Rhinitis in adults. This Phase IV study appraised the efficacy and safety of a combination of Paracetamol, Phenylephrine and Levocetirizine in treatment of common cold. Methodology–Of 185 enrolled, 156 patients completed the study. Safety assessment was made by inspecting the adverse events during trial. Efficacy assessment was made by decrementing in TSS and four point Likerttype scales. Results– Reduction in TSS from 5.05 (baseline) to 2.58 (day 3) and 0.61(day 5). One point reduction in Likert-type symptom scale from Moderate to Mild took just 3 days. Nearly all the patients had >50% reduction in symptom score at all visit and majority of patients had complete relief from the symptom. 20 episodes of adverse events occurred and were of mild intensity. Conclusion – A fixed-dose combination of Paracetamol, Phenylephrine and Levocetirizine is safe and effective in the treatment of Common Cold and Allergic Rhinitis in children.
Authors and Affiliations
Dr. Mayuresh Kiran
Keywords
Related Articles
- EP ID EP281342
- DOI -
- Views 90
- Downloads 0
An Epidemiological Study of Skeletal Tuberculosis
Background and Objectives: Skeletal tuberculosis is a major debilitating disease in our community. There was an increase in the nonresident keralites with skeletal tuberculosis attending our department for treatment in t...
Peripartum Management of Placenta Previa and Abruption Placenta in Rural Perspectives: A Real Test of Obstetrician’s Clinical and Surgical Skills
Introduction: Antepartum haemorrhage (APH) complicates 3-5% of all pregnancies. Abruption placenta and placenta previa contributes 60-70% of total causes of APH. It also predisposes a patient further for PPH and makes he...
A Comparative morphometric study of sacralised lumbar vertebra with the fifth lumbar and first sacral vertebra
Introduction: Unilateral or bilateral fusion of fifth lumber vertebra with the sacrum producing partial or complete sacralisation. due to many changes at this level .person suffers from low back pain with advancing age....
Coracoclavicular (Polyester) Suture Reconstruction of acute Type III Acromioclavicular Joint Dislocation – Surgical Technique and Outcome
Introduction: AC joint dislocation is among the common shoulder problems accounting for 9% of all shoulder injuries. AC joint injuries can be quite disabling especially in athletes and individuals who have to place heavy...
Bilateral Subclavian Artery Stenosis in the Young: Anaesthetic Implications
Abstract