EFFICACY OF ANTIOXIDATION AND ANTI- INFLAMMATION OF THE LEAF EXTRACTS OF BORRERIA HISPIDA
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2016, Vol 8, Issue 8
Abstract
Objective: The aim of the present study was to evaluate the total content of phenol, terpenoid and flavonoids from leaf extract of Borreria hispida which was collected from Tamilnadu regions. The leaf extract was also evaluated for antioxidant activity and in vitro anti-inflammatory activity.Methods: In the present investigation, the best accession was screened out through antioxidant activity by qualitative and quantitative methods. The leaf extract was evaluated for antioxidant activity by 1,1–diphenyl-2-picryl-hydrazyl (DPPH) radical scavenging assay. The in vitro anti-inflammatory activity was evaluated using albumin denaturation assay.Results: Among the five solvents, maximum antioxidant activity was found in the ethanolic extract of Thanjavur accession (81.3±0.1 %). Total content of phenol, terpenoid and flavonoids were quantified as 33.21±0.06 mg Gallic Acid Equivalents, 76.4±0.02 and 18.27±0.08 mg QE/g respectively. The maximum inhibition rate of albumin denaturation of Borreria hispida was found to be 89.3±0.5% at a dose of 10 mg/ml.Conclusion: It was concluded that the maximum percentage of antioxidant activity was found in Thanjavur accession which attributes the highest radical scavenging activity and the ethanolic leaf extract of Borreria hispida was exhibited a superior level of anti-inflammatory activity.
Authors and Affiliations
M. Chandrika, C. Chellaram
Keywords
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