Efficacy of ethyl acetate fraction of Cocos nucifera aqueous extract on the treatment of anemia
Journal Title: International Journal of Pharmaceutical Science Invention - Year 2017, Vol 6, Issue 9
Abstract
Cocos nucifera is a tropical coastal plant whose roots are used in traditional medicine to treat anemia. Its aqueous root extract stimulates erythropoiesis. This work aimed to test “in vivo” the ethyl acetate fraction of the extract. Method: Five groups of five wistar rats each were formed. Four groups were anemic with phenylhydrazine chloridrate at D0. From day 2 to day 15, the anemic groups receive by gavage either distilled water, vitafer (anti-anemic drug), the ethyl acetate fraction of the aqueous root extract of Cocos nucifera at a dose of 40 or 60 mg / Kg of body weight. The non-anemic group served as a control. Their blood was collected on days D0, D2, D7, D10 and D15 for the hemogram and the osmotic resistance of red blood cells. Results: At day 2, phenylhydrazine decreased significant decrease in hemoglobin and in the number of red blood cells, which were corrected at day 10 by the fraction of the extract with a dose-dependent effect. The extract fraction stimulated rapidly a release of immature macrocytes in the first week. The extract did not modify the number of platelets, suggesting some specificity on the red cell line. Conclusion: The ethyl acetate fraction of the aqueous root extract of Cocos nucifera stimulates erythropoiesis more rapidly than the crude extract. The biological activity was dose-dependent and may be related to the flavonoids whose mechanism of action needs to be elucidated.
Authors and Affiliations
Sènou M, Tchogou AP, Agbangnan DCP, Dougnon TV, Ogué P, Agossadou A, Lalèyè A, Loko F, Agbonon A, Sèzan A
Keywords
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