Efficacy of Garcinia kola Seed Ethanolic Extract on Haematological Parameters in Male Wistar Rats
Journal Title: Journal of Advances in Medical and Pharmaceutical Sciences - Year 2015, Vol 3, Issue 1
Abstract
The efficacy of Garcinia kola seed ethanolic extract on selected haematological parameters of male Wistar rats was investigated. Thirty (30) male Wistar rats weighing 150.42±3.98 g were divided into three groups (I, II and III) comprising ten animals each. Animals in group I (control) received 0.5 ml of distilled water while those in groups II and III were administered 100 and 200 mg/kg body weight of the extract respectively once daily for 21 days. After 21 days of extract administration, 5 rats from each group were sacrificed. Same was done after 42 days. Preliminary phytochemical screening of ethanolic extract of Garcinia kola seed revealed the presence of alkaloids, saponins, tannins, carbohydrates, steroids and flavonoids. The lethal dose (LD50) of the extract was found to be safe up to 5000 mg/kg body weight. The extract significantly (p<0.05) increased the red blood cell (RBC) count, packed cell volume (PCV), hemoglobin (Hb) concentration, white blood cell (WBC) count, platelet count and mean cell hemoglobin concentration (MCHC) in the plasma of the animals. The extract significantly (p<0.05) decreased the mean cell volume (MCV) and mean cell hemoglobin (MCH) in the plasma of the animals. Therefore, the ethanolic extract of Garcinia kola seed through its antioxidant property showed hematopoietic, stimulating and enhancing effects.
Authors and Affiliations
Denen Atsukwei, Eze Ejike Daniel, Samuel Odu Odeh, Moses Dele Adams, Ibrahim Samaila Malgwi, Patricia Chidimma Olih
Keywords
Related Articles
- EP ID EP342627
- DOI 10.9734/JAMPS/2015/15305
- Views 110
- Downloads 0
Enzyme link Immunosorbent Assay-based Detection of Hepatitis B Virus Infection in Correctional Facilities in Sokoto Metropolis, Sokoto State Nigeria
ELISA-Based detection of HBV infection in correctional facilities in Sokoto metropolis, Sokoto state Nigeria was carried out using a questionnaire survey to determine the associated risk factors of the disease and serolo...
Compositions of Thunbergia grandiflora Leaf and Root Essential Oils
Fresh samples of leaves and roots of Thunbergia grandiflora were collected from forest- reserved area, Ibadan, Nigeria for extraction of their volatile oils. Hydro-distillation method was used in an all-glass Clevenger a...
Drug Release Modification by Using Citric Acid and Glycerol Cross-linked Derivatives of Cashew (Anacardium occidentale L.) Gum
A derivative of cashew gum (CrosCCG) developed by cross-linking the gum with two cross-linking agents, citric acid and glycerol, has been used to modify drug release in Venlafaxine Hydrochloride tablets. Wet granulation...
Contextual Analysis and Perceptions of Health Workers on Migration: Perspective from Kenyatta National Hospital Staff, Nairobi Kenya
Aims: Migration of health workers constitutes a significant barrier to expanding health interventions. In Kenya, internal migration of workers, from rural to urban areas, is just as serious as international migration. He...
Effect of Drug-Drug Interactions by Association Rule Discovery among the Elderly
Objective: With the decline of the bodily function, the elderly increased polypharmacy frequency. The results lead to the danger for duplicate drug and drug interactions (DDIs). This study aims to analyze the effect of D...