Efficacy of Intrauterine infusion of granulocyte colony stimulating factor on patients with history of implantation failure: A randomized control trial
Journal Title: International Journal of Reproductive BioMedicine - Year 2016, Vol 14, Issue 11
Abstract
Background: Although pregnancy rate in in vitro fertilization-embryo transfer (IVF-ET) cycles has been increased over the preceding years, but the majority of IVF-ET cycles still fail. Granulocyte colony stimulating factor (GCSF) is a glycoprotein that stimulates cytokine growth factor and induces immune system which may improve pregnancy rate in women with history of implantation failure. Objective: The aim of this study was to evaluate GCSF ability to improve pregnancy rate in women with history of implantation failure Materials and Methods: 0.5 ml (300 µg/ml) GCSF was infused intrauterine in intervention group. Pregnancy outcomes were assessed based on clinical pregnancy. Results: The mean age of participants was 31.95±4.71 years old. There were no significant differences between demographic characteristics in two groups (p>0.05). The pregnancy outcome in GCSF group was improved significantly (p=0.043). Conclusion: GCSF can improve pregnancy outcome in patients with history of implantation failure.
Authors and Affiliations
Maryam Eftekhar, Sepideh Miraj, Nosrat Neghab
Keywords
Related Articles
- EP ID EP190695
- DOI -
- Views 127
- Downloads 0
Impacts of morphine addiction on spermatogenesis in rats
Background: There are numerous investigations on wide range of issues that disrupt regulatory spermatogenesis, individuals who are exposed to drug abuse faced infertility and immature spermatogenesis. Objective: The aim...
Assessment on the adverse effects of Aminoglycosides and Flouroquinolone on sperm parameters and male reproductive tissue: A systematic review
Background: Antibiotic therapies used in treatment of many diseases have adverse effects on fertility. This review analyzes previous comparative studies that surveyed the effects of two common groups of antibiotics on ma...
Effects of monosodium glutamate on apoptosis of germ cells in testicular tissue of adult rat: An experimental study
Background: Monosodium glutamate (MSG) is used as a flavoring and food seasoning. Some studies have reported the oxidative effects of using this substance on various tissues. Objective: This study has investigated the ef...
Association between electromagnetic field exposure and abortion in pregnant women living in Tehran
With great interest, we have read the article by Abad et al. entitled “Association between electromagnetic field exposure and abortion in pregnant women living in Tehran” that is published in International Journal of Rep...
Prevalence of premenstrual syndrome in Iran: A systematic review and meta-analysis
Background: Premenstrual syndrome (PMS) is a common disorder characterized by physical, mental and behavioral changes in the luteal phase of the menstrual cycle in the reproductive age women. Objective: The present study...