Efficacy of levetiracetam in neonatal seizures, a prospective open label comparative study
Journal Title: IP International Journal of Medical Paediatrics and Oncology - Year 2018, Vol 4, Issue 1
Abstract
Objective This study compares the efficacy of levetiracetam with phenobarbital in early onset seizures in term late preterm neonatesDesign Prospective randomized open label comparative studySetting study was carried out in tertiary care teaching hospital of south IndiaParticipants 78 terms and late preterm neonates admitted in NICU with neonatal seizuresIntervention Neonates with seizures were randomized into 2 groups to receive levetiracetam or phenobarbital as 1st line anti consultant in each groupResults As 1st line anti epileptic drug AED levetiracetam LEV was effective in 16 patients 41 and phenobarbital was effective in19 patients 487 where P value was not significant But mortality was more in phenobarbital group with death of 10 patients 256 and in LEV group death was only in 3 patients 77 statistically significant P value of 0033Conclusion levetiracetam and phenobarbital attained seizure control in less than 50 patients both were equally effective levetiracetam as 1st line anticonvulsant in early neonatal seizures leads to early seizure control and less mortality than use of phenobarbitalKeywords Levetiracetam Neonatal Seizures
Authors and Affiliations
R. H. Gobbur, G. Gaduputi
Keywords
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- EP ID EP482910
- DOI 10.18231/2455-6793.2018.0006
- Views 117
- Downloads 0
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