Efficacy of Metformin and Atorvastatin in Correction of Indices of Carbohydrate and Lipid Metabolism in Patients with Type 2 Diabetes Mellitus
Journal Title: Міжнародний ендокринологічний журнал - Year 2013, Vol 2, Issue 50
Abstract
This paper presents the results of metformin and atorvastatin use in patients with type 2 diabetes mellitus (DM). 25 patients with type 2 diabetes mellitus (DM) had been observed. Patients were treated with metformin and atorvastatin during 12 weeks. It is shown that use of metformin and atorvastatin significantly improves the indices of carbohydrate and lipid metabolism, reduces hyperinsulinemia and concomitant insulin resistance. Use of metformin and atorvastatin reduces daytime blood pressure level, improves myocardial diastolic function, reduces microalbuminuria. Among subjects with diastolic dysfunction, in 56.3 % patients the improvement of diastolic function was marked, its normalization has been observed in 18.8 % patients. During treatment with metformin and atorvastatin weight loss with the redistribution of fat deposits toward decrease of visceral obesity had been noted.
Authors and Affiliations
V. I. Pankiv
Keywords
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