Efficacy of Sorafenib in Patients with Hepatocellular Carcinoma Refractory to Transarterial Chemoembolization
Journal Title: Biomedical Journal of Scientific & Technical Research (BJSTR) - Year 2019, Vol 14, Issue 5
Abstract
Background: Transcatheter arterial chemoembolization (TACE) refractoriness is an indication for sorafenib treatment in patients with intermediate-stage hepatocellular carcinoma (HCC). This study aims at evaluating the efficacy of conversion of treatment to sorafenib on overall survival (OS) among trans arterial chemoembolization (TACE)-refractory HCC patients. Methods: This retrospective cohort study included 497 patients with HCC treated with TACE between January 2008 and December 2013 at the Kindai University Hospital. Among those patients, 56 were considered refractory to TACE. These TACE-refractory patients were grouped into two cohorts: a) patients who switched treatment from TACE to sorafenib (sorafenib group) and b) those who continued TACE (TACE group). We evaluated the OS of patients from the initial TACE.Results: Thirty-two patients were classified into the sorafenib group, while 24 patients were in the TACE group. The median OS from the initial TACE was 4.29 years in the sorafenib group and 2.14 years in the TACE group (p < 0.0010).Conclusion: Conversion of treatment to sorafenib might improve the OS in TACE-refractory patients with intermediate-stage HCC. Hence, conversion of treatment should be considered for HCC patients refractory to TACE.
Authors and Affiliations
Tadaaki Arizumic, Tomohiro Minami, Masatoshi Kudo
Keywords
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- EP ID EP585992
- DOI 10.26717/BJSTR.2019.14.002610
- Views 176
- Downloads 0
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