Ekspresja receptora CD27 na limfocytach T i B w tkance przerosłych migdałków gardłowych u dzieci chorych na wysiękowe zapalenie ucha środkowego
Journal Title: Otolaryngologia Polska - Year 2009, Vol 63, Issue 3
Abstract
Introduction: Adenoid has particular meaning to develop of immunological response to inflammations in upper respiratory inclusive middle ear. The mining of antigen CD27 on lymphocytes T and B in creation of memory cells is still unclear. Aim: CD27 on lymphocytes T and B has a crucial role in development of immune response against inflammatory state. Aim of this study was evaluation functions of lymhocytes with expression CD27 in hypertrophied adenoid in children with otitis media with effusion. Matherial and methods: We tested 24 children in examine group with hypertrophied adenoid and otitis media with effusion (OME), and 29 children in comparative group only with hypertrophied adenoid (HA). We also divided both groups into two groups, above 5 and over 5 years old. We made the research by flow cytometry method. We used anty-CD19, anty-CD3, antyCD5 and anty-CD27 monoclonal antibodies to examinations. Results: We showed the lowest percentage lymphocytes B CD5+ with expression of CD27 in subgroup older childen with otitis media with effusion (O.M.E. 22,43 ± 2,66%) in compartative to younger children in the same group (15,96 ±5,31%; p<0,005) and to older comparative subgroup (H.A. 15,50 ± 8,03; p<0,001). Percentages of B CD5 - cells with expression of CD27 was statistical lower in examinated group (7,25 ± 3,81) than in comparative group (H.A. 16,26 ± 5,82; p<0,04). In group with hypertrophied adenoid showed higher percentages of CD5 -CD27+CD19+ cells both in younger and older supgroup than in equivalent supgroups with O.M.E. Conclusions: Iteraction of CD27-CD70 regulates many functions of T and B lymphocytes. It seems that disorders humoral immunologucal answer in hypertrophied adenoids are supported to develop of otitis media with effusion.
Authors and Affiliations
Karol Ratomski, Beata Żelazowska-Rutkowska, Jolanta Wysocka, Bożena Skotnicka, Edwina Kasprzycka, Elżbieta Hassmann-Poznańska
Keywords
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