Embryo Protective Effect of Leaf Extract of Vitex Negundo Linn. in Adriamycin Induced Toxicity
Journal Title: Journal of Medical Science And clinical Research - Year 2014, Vol 2, Issue 4
Abstract
Herbal drugs are known to prevent toxicity in general & side effects of certain molecules in particular. Further, they are also being evaluated for their character of protecting embryo against such toxins & molecules. Administration of anticancer drugs such as Adriamycin during embryonic development in animals has been shown to cause foetal malformations. Since there are very few antioxidants and synthetic agents to prevent the toxicity in embryo, present investigation was carried out, in which herbal leaf extract of Vitex negundo Linn. was proved to have effect of protecting chick embryo from Adriamycin (ADR). The results of present study clearly reveal the toxicity of drug on the developing chick embryos. A significant decrease in weight of ADR-treated group was due to decreased energy supply as evidenced by the altered properties of macromolecules of yolk-sac & reduction in extra-embryonic vascular network which, in turn, reduced the nutrient transport, hence detrimental to the embryonic growth & damage to vital tissue like kidney when compared with the control. A momentous decrease in the volume of amniotic fluid is believed to be caused due to decrease in the amount of albumin entering the amniotic fluid via sero-amniotic connection that constricts the perforation of sero-amniotic plate.
Authors and Affiliations
Hitesh U. Shingadia
Keywords
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