Enalapril enhances the anticonvulsant activity of lamotrigine in the test of maximal electroshock.
Journal Title: Pharmacological Reports - Year 2013, Vol 65, Issue 4
Abstract
The aim of this study was to find out whether angiotensin-converting enzyme (ACE) inhibitors, enalapril and cilazapril, affect the anticonvulsant action of some second-generation antiepileptics, lamotrigine (LTG), topiramate (TPM) and oxcarbazepine (OXC).
Authors and Affiliations
Krzysztof Łukawski, Tomasz Jakubus, Agnieszka Janowska, Grzegorz Raszewski, Stanisław Czuczwar
Keywords
Related Articles
- EP ID EP157350
- DOI -
- Views 101
- Downloads 0
Influence of long-term leflunomide treatment on serum amyloid concentration in rheumatoid arthritis patients.
Rheumatoid arthritis (RA) is a chronic, inflammatory disease that requires intervention with disease-modifying antirheumatic drugs (DMARDs) to stop disease progression. Leflunomide (LEF) is a DMARD with anti-inflammatory...
Benzylpenicillin inhibits the renal excretion of acyclovir by OAT1 and OAT3.
Background: Acyclovir is acyclic guanosine derivative. Benzylpenicillin (PCG) is a β-lactam antibiotic. The purpose of this study was to investigate the pharmacokinetic drug-drug interaction (DDI) between PCG and acyclov...
Pseudo-epileptic seizures in children are not associated with enhanced plasma level of allopregnanolone.
Among neurosteroids, allopregnanolone is the most potent endogenous positive modulator of GABA(A) receptors, and disturbances in its release may play a role in pathomechanism of some neurological and psychiatric disorder...
Inhibitor of cyclooxygenase-2 protects against amyloid beta peptide-evoked memory impairment in mice.
Alzheimer's disease (AD) results in an impairment of memory and behavior. It is accepted that amyloid beta (Abeta) peptides are responsible for the etiopathology of AD, but the precise signaling pathways leading to the d...
Oral administration of lithium increases tissue magnesium contents but not plasma magnesium level in rats.
The aim of this work was to determine the influence of different doses of lithium on magnesium concentration in plasma and tissues of rats. For a period of eight weeks rats had been provided with aqueous solutions of Li(...