Endocannabinoid mechanisms of pain modulation
Journal Title: The AAPS Journal - Year 2006, Vol 8, Issue 4
Abstract
Cannabinoids are antinociceptive in animal models of acute, tissue injury-, and nerve injury-induced nociception. This review examines the biology of endogenous cannabinoids (endocannabinoids) and behavioral, neurophysiological, and neuroanatomical evidence supporting the notion that cannabioids play a role in pain modulation. Behavioral pharmacological approaches, in conjunction with the identification and quantification of endocannabinoids through the use of liquid and gas chromatography mass spectrometry, have providedinsight into the functional roles of endocannabinoids in pain modulation. Here we examine the distribution of cannabinoid receptors and endocannabinoid-hydrolyzing enzymes within pain modulatory circuits together with behavioral, neurochemical, and neurophysiological studies that suggest a role for endocannabinoid signaling in pain modulation. This review will provide a comprehensive evaluation of the roles of the endocannabinoids 2-arachidonoyl-glycerol and anandamide in stress-induced analgesia. These findings provide a functional framework with which to understand the roles of endocannabinoids in nociceptive processing at the supraspinal level.
Authors and Affiliations
Andrea G. Hohmann, Richard L. Suplita
Keywords
Related Articles
- EP ID EP681826
- DOI 10.1208/aapsj080479
- Views 97
- Downloads 0
Advancing Product Quality: a Summary of the Inaugural FDA/PQRI Conference
On September 16 and 17, 2014, the Food and Drug Administration (FDA) and Product Quality Research Institute (PQRI) inaugurated their Conference on Evolving Product Quality. The Conference is conceived as an annual forum...
Role of monoamine transporters in mediating psychostimulant effects
Monoamine transporters such as the dopamine (DA) transporter (DAT) and the vesicular monoamine transporter-2 (VMAT-2) are critical regulators of DA disposition within the brain. Alterations in DA disposition can lead to...
Predictive Models of Diffusive Nanoparticle Transport in 3-Dimensional Tumor Cell Spheroids
The rapidly evolving nanotechnology field highlights the need of better understanding the relationship between nanoparticle (NP) properties and NP transport in solid tumors. The present study tested the hypothesis that t...
Impact-Insertion Applicator Improves Reliability of Skin Penetration by Solid Microneedle Arrays
In this study, high-density arrays (576 microneedles on a 5 × 5-mm backplate, gifted by Bosch, Germany, Stuttgart) with a microneedle length of 200 μm were used (Fig. 1 )....
A pragmatic approach to the design of population pharmacokinetic studies
The publication of a seminal article on nonlinear mixed-effect modeling led to a revolution in pharmacokinetics (PKs) with the introduction of the population approach. Since then, interest in obtaining accurate and preci...