Endothelial Dysfunction Markers as Predictive of Nephropathy in Pediatric Type 1 Diabetes
Journal Title: Scholars Journal of Applied Medical Sciences - Year 2017, Vol 5, Issue 10
Abstract
Abstract: Recent studies found a correlation between endothelial dysfunction and the development of diabetic nephropathy. Soluble intracellular adhesion molecule-1(sICAM) and nitric oxide metabolites (NOx) are known markers for endothelial dysfunction. This study aims at validation of the correlation between sICAM and NOx levels with the degree of microalbuminuria in pediatric type-1 diabetic patients. Thirty children with Type 1 diabetes (T1D) were enrolled for the study and compared to thirty healthy age and gender matched non-diabetic controls. In both groups, the levels of sICAM1, HBA1cpercentage, nitric oxide metabolites, and spot collection of urinary albumin / mg creatinine were measured. The results revealed that children with T1D had significantly higher glycated hemoglobin (HbA1c %) values versus the control group (P<0.05). The mean serum sICAM-1 concentration was significantly higher in T1D children versus the control group (P<0.05). 0n the other hand, the mean serum nitric oxide metabolite (NOx) showed a significant reduction (P< 0.05) in the T1D. The mean urinary albumin / mg creatinine was significantly higher (P< 0.05) in diabetic children than in control group. Correlation analysis showed a significant (P< 0.05) positive correlation between the levels of sICAM-1 µalbuminuria and a negative correlation between microalbuminuria and NOx level. It could be concluded that sICAM1and NO may play important roles in the pathophysiology and progression of endothelial dysfunction and its related disorders as diabetic nephropathy in T1D which should be considered in the monitoring the disease as well as for developing effective preventive and therapeutic interventions to prevent or retard overt diabetic nephropathy. Keywords:T1D, sICAM1, NOx, endothelial dysfunction, nephropathy
Authors and Affiliations
Ali KhairrallahAlzahrani
Keywords
Related Articles
- EP ID EP372073
- DOI -
- Views 79
- Downloads 0
A Study of Spectrum of Organisms and Their Sensitivity Pattern in Patients Presenting with Acute Exacerbation of Chronic Obstructive Pulmonary Disease
Abstract: Chronic obstructive pulmonary disease is preventable and treatable disease. COPD is the fourth leading cause of death and affects >10 million persons in the United States. COPD is also a disease of i...
Study of clinical profile, etiology and immediate outcome in Non-traumatic coma in children
Abstract: Etiology of coma and clinical status at the time of presentation are likely predictors of outcome in cases of non-traumatic coma. The present study included of clinical profile, etiology of non-traumatic coma a...
Yuvika- A Report of Life Skills Training Workshop for Adolescent Girls in Rural Maharashtra
Adolescence is a period of biological, cognitive and social transition. Key aspects of adolescents’ lives include sexual and reproductive health, education and nutrition. Physical and sexual abuse, the lack of autonomy a...
Serum enzyme levels as biomarkers in malaria
Malaria is one of the most serious diseases especially of the tropical world. Pathophysiological process involves both centrilobular liver damage and red blood cells destruction. As a result, enzymes present in these cel...
A Study of Ventilator Support and Clinical Outcome in Patients of Snake Bite in Tertiary Care Centre
Abstract: Snake bite envenomation is one of the common acute lives threatening medical condition presenting to the emergency with significant morbidity and mortality. To study the use of ventilator support its duration a...