ENDURANCE EXERCISE TRAINING AND DIFERULOYL METHANE SUPPLEMENT: CHANGES IN NEUROTROPHIC FACTOR AND OXIDATIVE STRESS INDUCED BY LEAD IN RAT BRAIN
Journal Title: Biology of Sport - Year 2013, Vol 30, Issue 1
Abstract
For many years it has been known that lead is life-threatening, not only as an air pollutant but also because of it has been associated with several conditions including degenerative disease of the nervous system. In the current study we investigated neuroprotection effects of exercise training and/or curcumin on lead acetate-induced neurotoxicity in the rat hippocampus. Forty rats were randomly divided into five groups: 1) lead acetate, 2) curcumin, 3) endurance training, 4) training+curcumin, and 5) sham. The rats in the training groups performed treadmill running consisting of 15 to 22 m/min for 25 to 64 min, 5 times a week for 8 weeks. All groups except sham received lead acetate (20 mg/kg), whereas the sham group received curcumin solvent. In addition, the curcumin and training+curcumin groups received curcumin solution (30mg/kg) intra peritoneally. Chronically administration of lead acetate resulted in a significantly increase in the malondialdehyde (MDA) in plasma, but not in hippocampus. In addition, it led to significantly decreased brain-derived neurotrophic factor (BDNF) in hippocampus and total antioxidant capacity (TAC) levels, as compared to sham group. Treadmill running, curcumin supplementation, or both resulted in a significant decrease in MDA levels and significantly increased BDNF and TAC levels, as compared to lead acetate group. These results provide a rationale for an inhibitory role of curcumin and regular exercise in the attenuation of lead-induced neurotoxicity.
Authors and Affiliations
Valiollah Dabidi Roshan, Somayeh Hosseinzadeh, Soleiman Mahjoub, Mahdi Hosseinzadeh, Jonathan Myers
Keywords
Related Articles
- EP ID EP59141
- DOI -
- Views 136
- Downloads 0
Moral attitudes towards doping – what do athletes on the verge of maturity value?
The aim of the present study was twofold: a) to verify the previously detected regularities in a group of subjects larger than the one employed in a pilot study, and b) to define the internal structure of the hierarchy o...
EPIDEMIOLOGY OF TRACK & FIELD INJURIES: A ONE YEAR EXPERIENCE IN ATHLETIC SCHOOLS
The purpose of this study was to record injuries in track & field events that were sustained by students who attended the athletic schools during a one-year period. From September 2009 to May 2010, the researcher...
Effects of 12-Week’s Tai Chi Chuan Practice on the Immune Function of Female College Students Who Lack Physical Exercise
Objective: The present study investigated the effects of 12 weeks’ tai chi chuan (TCC) practice on the immune function of female college students. Method: 60 female college students (19.3 ± 1.8 years) were recruited and...
The effect of inhaling concentrated oxygen on performance during repeated anaerobic exercise
The objective of the pilot study was to test the effect of inhaling 99.5% oxygen on recovery. The source of concentrated oxygen was O-PUR (Oxyfit). Research subjects completed two thirty-second Wingate tests at an interv...
NEW EQUATIONS TO DETERMINE EXERCISE INTENSITY USING DIFFERENT EXERCISE MODES
The purpose of this study was to determine new equations from the relationship of % ·VO2max versus %HRmax, based on direct measures of oxygen uptake, in four exercise modes (leg cycling, rowing, stepping and running), in...