Eosinophilic esophagitis—Where are we today?
Journal Title: Jornal de Pediatria - Year 2019, Vol 95, Issue 3
Abstract
Objective The objective of this review is to provide an overview of the practical diagnostic and therapeutic approaches to eosinophilic esophagitis and to increase the visibility of the disease among pediatricians. Sources A search of the MEDLINE, Embase, and CINAHL databases and recent consensus statements and guidelines were performed. Summary of the findings The definition of eosinophilic esophagitis is based on symptoms and histology. It is important to rule out other diseases associated with esophageal eosinophil-predominant inflammation. It is not yet clear whether the increased prevalence is due to a real increase in incidence or a result of increased awareness of the disease. Various options for management have been used in pediatric patients, including proton pump inhibitors, dietary restriction therapies, swallowed topical steroids, and endoscopic dilations. More recently, proton pump inhibitor-responsive esophageal eosinophilia and eosinophilic esophagitis have been contemplated on the same spectrum, and proton pump inhibitors should be considered the initial step in the treatment of these patients. Conclusions Eosinophilic esophagitis is a relatively new disease with a remarkable progression of its incidence and prevalence in the past two to three decades, and diagnostic criteria that are constantly evolving. It is important to better understand the pathogenesis of the disease, the predisposing factors, the natural history, and the categorization of varying phenotypes to develop diagnostic and therapeutic strategies that meet the clinical needs of patients.
Authors and Affiliations
Cristina Ferreira
Keywords
Related Articles
- EP ID EP575265
- DOI 10.1016/j.jped.2018.06.012
- Views 83
- Downloads 0
Influence of AIDS antiretroviral therapy on the growth pattern
Objectives Human immunodeficiency virus infection can result in the early impairment of anthropometric indicators in children and adolescents. However, combined antiretroviral therapy has improved, in addition to the imm...
Signs and symptoms of developmental abnormalities of the genitourinary tract
Objective The abnormalities of the genitourinary tract development are the leading cause of chronic kidney disease (CKD) in children. The diagnosis of this disease in Brazil is late and incomplete, which results in incre...
Validation of the Brazilian version of the Pediatric Obstructive Sleep Apnea Screening Tool questionnaire
Objective To validate the Pediatric Obstructive Sleep Apnea Screening tool for use in Brazil. Materials and methods The Brazilian version of this questionnaire, originally validated and tested in the United States, was...
Food insecurity and social support in families of children with sickle-cell disease
Objective To examine the associations between food insecurity (IA) and social support in families of children with sickle-cell disease (DF). Methods This cross-sectional study in families of 190 children from five to ni...
Use of fibers in childhood constipation treatment: systematic review with meta-analysis
Objective To gather current evidence on the use of fiber for constipation treatment in pediatric patients. Source of data Systematic review with meta-analysis of studies identified through Pubmed, Embase, LILACS and Coc...