Epidemiological and Biological Parameters of Monoclonal Plasma Cell Dyscrasias in Thirty One Patients Consulting a Moroccan Pasteur Institute
Journal Title: International Blood Research & Reviews - Year 2015, Vol 3, Issue 2
Abstract
Aims: To describe epidemiological and biological features of patients with monoclonal plasma cell dyscrasias. The patients were seen at the Moroccan Pasteur Institute in Casablanca during a period of two years and four months. Place and Duration of Study: Laboratory of immunochemistry, Pasteur institute, Casablanca, Morocco. From April 2006 to July 2006. Methodology: Thirty one case notes of patients who had a serum or urine monoclonal gamma or beta globulin spike were assessed. Results: The mean age of the patients was 54.7±10.7 years (range, 26–72 years) and there were more females with a sex ratio 0.82. 66.7% of the patients had a monoclonal gamma globulin peak revealed by electrophoresis. According the results of performed agar gel immuno-electrophoresis, 48% of them had monoclonal immunoglobulin G (IgG) antibodies, followed by class IgA with 29% of cases. Moreover, 55% of the patients were Kappa-chain positive, while 45% were Lambda-chain positive. Assessment of prognostic factors of some patients demonstrated an increased erythrocyte serum rate (66.7% of cases), anemia (50% of cases), a raised of calcium serum levels (37.5% of cases) and β2-microglobulin serum levels were higher than 3.5 mg/l (33.3% of cases). In addition, the mean concentration of proteins was 91 g/l (58.6% of cases), low levels of albumin below 36 g/l were observed (63% of cases) and the monoclonal component levels were above 30 g/l (55.6% of cases). Conclusion: Some of our records were different from those of other series: our patients were younger with a slight predominance of female individuals. Others were consistent mainly with the more frequently observed monoclonal gamma-globulin peak, and also with the assessed levels of IgG, which is known as the most common isotype in plasma cell disorders. On the other hand, a rise of prognostic factors levels was also noted except for C-reactive protein. Nevertheless, our study pointed out that the majority of patients didn’t have a rigorous monitoring of their disorders by carrying out hematological and serological examinations.
Authors and Affiliations
Ilham Zahir, Abderahman Bellik
Keywords
Related Articles
- EP ID EP242429
- DOI 10.9734/IBRR/2015/15692
- Views 116
- Downloads 0
Approach to Anaemia Diagnosis in Developing Countries: Focus on Aetiology and Laboratory Work-Up
Introduction: Anaemia is a significant public health problem in developing countries. Anaemia is never normal. The etiology of the anaemia should always be sought. Diagnosis of its cause and early treatment is crucial to...
Prevalence of Clinically Significant Alloantibodies among Transfusion Requiring Patients in a Tertiary Hospital in Sokoto, Nigeria
Aim: No data are available regarding the frequencies of clinically significant alloantibodies among patients requiring transfusion in Sokoto North western Nigeria. We intend to provide information on the prevalence of cl...
Effect of Calpurnia aurea Seed Extract on HAART Induced Haematotoxicity in Albino Wistar Rats
Aim: To investigate the effect of Calpurnia aurea seeds extract on highly active antiretroviral therapy (HAART), first phase regimens (Lamivudine + Efavirenz + Zidovudine) induced heamtotoxicity in rats. Study Design: Th...
Blood Group Phenotype Frequencies in Blood Donors in the Northeast of Democratic Republic of Congo
Background and Aims: To know blood group antigen frequencies in a population has various benefits as the assessing risk of alloimmunization, the providing antigen-negative compatible blood to patients with multiples anti...
Evaluation of Certain Blood and Biochemical Changes of Nile Catfish (Clarias gariepinus) Exposed to Mercuric Chloride with Particular Reference to Erythrocyte Morphological Anomalies
Sub-lethal toxicity of mercuric chloride (0.0002, 0.002, 0.02mg/L) in Nile catfish (Clarias gariepinus) after long-term (14 days) of exposure in the present study was investigated by measurement of some selective hematol...