Erythrocyte CAT, GPx and GR levels in pregnant anemic woman
Journal Title: Medpulse International Journal of Biochemistry - Year 2017, Vol 5, Issue 1
Abstract
Pregnancy is characterized by a high-energy demand and an increased oxygen requirement. This is a condition exhibiting increased susceptibility to oxidative stress. Hydrogen peroxide is a harmful by-product of many normal metabolic reactions. Catalase and Glutathione peroxidase are the antioxidant enzymes produced naturally within the body. These enzymes help the body to convert hydrogen peroxide into water. Glutathione reductase catalyzes the reduction of glutathione disulfide (GSSG) to the sulfhydryl form Glutathione (GSH), which is a critical molecule in resisting oxidative stress and maintaining the reducing environment of the cell. We have estimated the catalase and glutathione peroxidase and glutathione reductase activity in the erythrocytes of pregnant anemic patients and these levels were significantly low as compared to control. Our results suggest that oxidative stress in pregnant anemic women causes the deficiency in antioxidant enzymes, which is a result of enormous production of ROS in the system. These findings may also indicate a possible link between decreased antioxidants and increased levels of cells alterations due to oxidative damage, supporting the idea that there is a persistent oxidative stress in pregnant anemic women.
Authors and Affiliations
S B Gaikwad, K N Pujari, P A Waghmare
Keywords
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