ESBL PRODUCING ENTEROBACTERIACEAE ISOLATES – PREVALANCE AND THEIR SUSCEPTIBILITY PATTERNS
Journal Title: Journal of Biomedical and Pharmaceutical Research - Year 2014, Vol 3, Issue 1
Abstract
Background: Antimicrobial resistance seen among many Enterobacteriaceae isolates, especially those expressing extended spectrum beta lactamase (ESBL) enzymes are on the rise. This has limited our treatment options and made it very difficult to control these infections. Aim: To determine the prevalence of ESBL productions among Enterobacteriaceae isolates and also study their susceptibility patterns. Methods: A total of 220 clinical isolates of Enterobacteriaceae were screened for ESBL production by using five screening drugs.those resistant any one of the drugs were further tests for confirmation of ESBL production by Double disc synergy test (DDST). The ESBL producers were further studied for susceptibility patterns to other antibiotics. Results: Among the 220 isolates 117 (53.17%) were found to ESBL producers. These ESBL producers were most sensitive to meropenem, piperacillin/tazobactum and least sensitive to co-trimoxazole . Conclusions: The prevalence of multidrug resistant ESBL producers is very high and there is an urgent need to rationalize the use of antibiotics and minimize their misuse.
Authors and Affiliations
V. N. Venkatesh| Professor and Head, Department of Microbiology, Basaveshwara Medical College & Hospital, Chitradurga, Karnataka, India, Sudhindra. K. S| Associate Professor, Department of Microbiology, Basaveshwara Medical College & Hospital, Chitradurga, Karnataka, India, Ravish Kumar. M| Assistant Professor, Department of Microbiology, Basaveshwara Medical College & Hospital, Chitradurga, Karnataka, India, Shwetha. D. C| Assistant Professor, Department of Microbiology, Basaveshwara Medical College & Hospital, Chitradurga, Karnataka, India, T. K. Srinivas Shetty| Assistant Professor, Department of Microbiology, Basaveshwara Medical College & Hospital, Chitradurga, Karnataka, India, Nirmala Grace. B| Assistant Professor, Department of Microbiology,Guntur Medical College, Guntur, Andhra Pradesh, India
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