ESTROGENIC ACTIVITY OF MUCUNA PRURIENS IN SWISS ALBINO MICE
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2011, Vol 2, Issue 4
Abstract
Various parts of Mucuna pruriens have been claimed to be useful in conditions like dysmenorrhoea, amenorrhoea, menorrhagia, infertility in females and lack of libido, stamina, sex drive, spermatorrhea, impotency in males. In present study, estrogenic activity of M. pruriens in mice was studied. The ovariectomy of selected mice was performed by flank method under mild ether anesthesia. Drugs under study were administered for fourteen days. One day after the administration of last dose, at necropsy, uteri were isolated, squeezed and weighed, under moist condition (freshly) for Assay of water uptake and under dehydrated condition for uterine weight assay. In present study, significant uterine weight gain was observed in moist and dry condition which might be due to the presence of estrogenic activity in the plant M. pruriens which was administered in the ethanolic extract form to the mice. Thus, it can be concluded that, the M. pruriens posses a good estrogenic activity.
Authors and Affiliations
Sushant Parekar , Arju Somkuwar
Keywords
Related Articles
- EP ID EP124730
- DOI -
- Views 124
- Downloads 0
FREE RADICALS, EPILEPSY AND ANTI-OXIDANT: AN OVERVIEW
Epilepsy is a common and heterogeneous disorder arising from biochemical and molecular events in the brain that are incompletely understood. Oxidative stress is emerging as a mechanism that may play an important role in...
PHYTOCHEMICAL SCREENING, TOTAL PHENOLIC CONTENT, ANTIBACTERIAL AND ANTIOXIDANT ACTIVITY OF WILD EDIBLE MUSHROOM PLEUROTUS OSTREATUS
The methanolic and aqueous extracts of dried wild edible mushroom were analyzed for phytochemical screening, antibacterial, antioxidant activity (DPPH) and total phenolic content. The preliminary phytochemical results sh...
PHYTOCHEMICAL SCREENING OF SECONDARY METABOLITES FROM MYXOPYRUM SERRATULUM A.W. HILLS BY GC-MS, HPTLC ANALYSIS
Myxopyrum serratulum is a valuable medicinal plant widely distributed in Western Ghats at the altitude of 600-900m. Traditionally, the leaves of the plant used to treat asthma, cough diabetes and nerve complaints. The cu...
IN VITRO ANTIMICROBIAL AND ANTIOXIDANT ACTIVITY OF GINKGO BILOBA BARK EXTRACT
Ginkgo biloba also called as Maidenhair Tree, belongs to the family Ginkgoaceae. In this study, the hydro-Methenolic extract from bark of Ginkgo biloba was screened for their in vitro antimicrobial and antioxidant activi...
A REVIEW ON LEMON GRASS: AGRICULTURAL AND MEDICINAL ASPECT
Lemongrass (Cymbopogan flexuosus and Cymbopogan Citraus) is regarded as one of the grass which is commonly available in India and abroad. It is widely used in different conditions of pain and discomfort. The oil (Lemongr...