Evaluating the Antischistosomal Activity of Crude Extracts of Carica Papaya against Schistosoma Mansoni: the Interplay of Cellular and Humoral Immunity
Journal Title: Journal of Biomedical and Pharmaceutical Research - Year 2013, Vol 2, Issue 1
Abstract
Carica papaya is widely used in different parts of Kenya for the treatment of intestinal helminthes. The present study was designed to evaluate the anti-schistosomal effect of a methanolic and aqueous extract of Carica papaya seeds in schistosoma infected mice. Laboratory mice were infected with a single dose of Schistosoma mansoni cercariae. The extracts were administered orally at a dose of 300 mg/kg body weight in 200μl suspension to infected mice two days apart. Praziquantel was the reference drug used in the experiments.Two weeks post-treatment; all animals were sacrificed to evaluate the efficacy of Carica papaya in treatment of the infection. Significant effect of the extracts was observed against schistosomal infected mice. Carica papaya methanol extract was found more effective against schistosomes recording more less recovery while Carica papaya aqueous extract recorded more recovery. Detectable levels of cytokines were also recorded during infection and after treatment with a marked rise in SWAP specific IL5. These data support the use of Carica papaya based medicines as antischistosomal agents where acces to commercial drugs is restricted. These findings provide solid scientific evidence to support the traditional medicinal uses of these extracts and indicate a promising potential of this plant for medicinal purposes. There is also need for detailed scientific study of traditional medicinal practices to ensure that valuable therapeutic knowledge of this plant is preserved and also to provide scientific evidence for their efficacy.
Authors and Affiliations
Mokua John Mose*| Department of Medical Laboratory Science, School of Medicine and Health Sciences, Kenya Methodist University, Nairobi, Kenya., Helen Kutima| Department of Zoology, Faculty of Science, Jomo Kenyatta University of Agriculture and Technology, P.O. Box 62000-00200, Nairobi, Kenya., Rebecca Waihenya| Department of Zoology, Faculty of Science, Jomo Kenyatta University of Agriculture and Technology, P.O. Box 62000-00200, Nairobi, Kenya., Dorcas Yole| Department of Biological sciences, Kenya Polytechnic University College, P.O Box 52428-00200 Nairobi, Kenya
Keywords
Related Articles
- EP ID EP1587
- DOI -
- Views 374
- Downloads 23
HYPEROSMOLALITY ALTERS MACROPHAGE SYNTHESIS AND REGULATION; ROLE OF PHOSPHOLIPASE C ENZYMES
High NaCl stimulates activity of the osmoprotective transcription factor TonEBP/OREBP by enhancing its phosphorylation, transactivating ability, and localization to the nucleus. PLC γ plays an important role in these mec...
OPTIMIZATION OF RHAMNOLIPID BIOSURFACTNT PRODUCTION BY STREPTOMYCES MATENSIS (NBRC 12889T) USING PLACKETT-BURMAN DESIGN
Surfactants produced by microorganisms are known as biosurfactants. Biosurfactants are becoming important biotechnology products for industrial and medical applications due to their specific modes of action, low toxicity...
Formulation and In-Vitro Evaluation of Immediate Release Tablets of Losartan Potassium Using Different Superdisintegrants
In the present study an attempt has been made to prepare the various trails (T1 to T7) of immediate release tablets of losartan potassium by using a suitable diluent (Microcrystalline cellulose PH 101), a binder (Pregel...
A REVIEW ON ACNE
Acne is a cutaneous pleomorphic disorder of the pilosebaceous unit involving abnormalities in sebum production and is characterized by both inflammatory (papules, pustules and nodules) and non inflammatory (comedones, op...
CYTOPROTECTIVE EFFICACY OF DRDE-07 AND DRDE-30 AGAINST CISPLATIN INDUCED NEPHROTOXICITY
Aim: The objective of the study was to investigate the cytoprotective action of DRDE-07 and DRDE-30 against cisplatin induced nephrotoxicity in mice. Subjects and Methods: Randomly bred Swiss female mice (25-30 g) were s...