Evaluating the clinical applications of visual evoked potentials in patients presenting with visual dysfunctions - A retrospective study
Journal Title: National Journal of Physiology, Pharmacy and Pharmacology - Year 2018, Vol 8, Issue 7
Abstract
Background: The clinical applicability of visual evoked potential (VEP) tests has been progressively extending in neuro-ophthalmological workups. The role in monitoring and follow-ups are emerging as even more useful applications. Aims and Objectives: The present study aimed to assess the clinical role of pattern-reversal VEP (PRVEPs) in visual disorders with presumptive optic nerve involvement. Materials and Methods: PRVEP records of 58 patients with unilateral/bilateral visual loss in a study period of 1½ year were retrospectively analyzed. P100 latencies and N75-P100 amplitudes were compared with those of 60 age and sex-matched controls. Variations beyond three standard deviations were applied to define significant abnormalities. PRVEP records obtained by follow-up in some conditions were also assessed. Results: Traumatic optic neuropathy (32.76%) was the most common condition confronted, with major PRVEP finding as absent waveforms/reduced amplitudes. Monitoring of VEP records revealed improvement in 50% of patients on corticosteroid therapy. Functional visual disorders constituted 27.6% with 93.75% of subjects confirmed by PRVEP. Ethambutol-induced toxic optic neuropathy (20.69%) was associated with significant P100 delay bilaterally, in the majority. Out of which, 50% showed improved PRVEP records after 1 month of cessation of drug. Multiple sclerosis and optic neuritis though rarer conditions (3.44% and 6.89%, respectively) exhibited characteristic electrophysiological findings which helped confirming the diagnosis. Diabetic optic neuropathy (3.4%) and some very rare conditions also constituted the referrals. Conclusion: VEPs provides sensitive adjuncts to diagnosis in various visual disorders and contributes as important monitoring tools for objectively assessing the recovery and ophthalmological status.
Authors and Affiliations
Sangeeta Gupta, Punita Garg, Gaurav Gupta
Keywords
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- EP ID EP491504
- DOI 10.5455/njppp.2018.8.0309519032018
- Views 75
- Downloads 0
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