EVALUATION OF ANTI-INFLAMMATORY ACTIVITY OF KANDANGKATHIRI KIRUTHAM IN ANIMAL MODEL
Journal Title: International Journal of Pharmacognosy - Year 2015, Vol 2, Issue 11
Abstract
Kandangkathiri Kirutham (ghee of Solanum xanthocarpum) is a Siddha herbal formulation mentioned in Siddha textbook for the treatment of Ullnaakku Azharchi (Tonsillitis). It contains leaf juice of Kandangkathiri (Solanum xanthocarpum), cow’s ghee, the paste of raw drugs namely Sittrarathai (Alpinia officinarum), Sittramutti (Sida cordifolia), Nerunjil ver (Tribulus terrestris), Chukku (Zingiber officinale), Milagu (Piper nigrum), Thippili (Piper longum) respectively. In the present study, the anti-inflammatory activity of Kandangkathiri Kirutham is evaluated by carrageenan-induced paw edema in rats using Diclofenac sodium as the standard drug. The animals were divided into 4 groups, of which, Group I (Negative control) is injected with carrageenan into the sub-plantar region of the hind paw of rats, Group II & Group III are injected with carrageenan + Kandangkathiri Kirutham (100 mg/kg) & (200 mg/kg) respectively. Group IV is injected with carrageenan + Standard Diclofenac sodium (50 mg/kg). The change in hind paw volume was measured using plethysmometer and expressed as mean paw volume of the rats. The formulation showed significant reduction of paw volume in rats. The results suggest that Kandangkathiri Kirutham has anti-inflammatory activity in rats.
Authors and Affiliations
S. Chitra et al.
PHYTOCHEMICAL SCREENING AND ANTIOXIDANT ACTIVITY OF JUSTICIA TRANQUEBARIENSIS AND BAUHINIA RACEMOSA
Introduction: The phytochemicals in medicinal plants are defined as bioactive non-nutrient plant compounds in fruits, vegetables, and grains that have been linked to reducing the risk of major chronic diseases. The medic...
ARECA CATECHU: ENFOLDING OF HISTORICAL AND THERAPEUTIC TRADITIONAL KNOWLEDGE WITH MODERN UPDATE
Areca catechu has been in use as a social drug from the time immemorial and usually chewed by at least 10% of the world’s population. Areca catechu commonly known as supari consists of dried ripe nuts and belongs to the...
HERBS AND HERBAL TEAS WITH ANTIOXIDANT PROPERTIES COMPARABLE TO OR SUPERIOR THAN THOSE OF CAMELLIA SINENSIS
The antioxidant properties of 20 herbs and 28 herbal teas were analyzed in comparison with those of Camellia sinensis based on total phenolic content (TPC), free radical scavenging (FRS) activity, ferric reducing power (...
HEPATOPROTECTIVE AND ANTIOXIDANT ACTIVITY OF SESBANIA GRANDIFLORA AGAINST CCl4-INDUCED HEPATIC INJURY IN RATS
A phytotherapeutic approach to modern drug development can provide many invaluable drugs from traditional medicinal plants. Medicinal plants have been considered as an important therapeutic aid for alleviating ailment of...
CURRENT ADVANCES IN NANOTECHNOLOGY FOR DELIVERY OF ANTI-DIABETIC DRUGS: A REVIEW
Diabetes mellitus (DM) is being one of the major causes of morbidity and mortality, which seriously threatens the health of human beings. Worldwide around 366 million people are found to be affected by diabetes. DM is a...