EVALUATION OF ANTI-INFLAMMATORY ACTIVITY OF KANDANGKATHIRI KIRUTHAM IN ANIMAL MODEL

Journal Title: International Journal of Pharmacognosy - Year 2015, Vol 2, Issue 11

Abstract

Kandangkathiri Kirutham (ghee of Solanum xanthocarpum) is a Siddha herbal formulation mentioned in Siddha textbook for the treatment of Ullnaakku Azharchi (Tonsillitis). It contains leaf juice of Kandangkathiri (Solanum xanthocarpum), cow’s ghee, the paste of raw drugs namely Sittrarathai (Alpinia officinarum), Sittramutti (Sida cordifolia), Nerunjil ver (Tribulus terrestris), Chukku (Zingiber officinale), Milagu (Piper nigrum), Thippili (Piper longum) respectively. In the present study, the anti-inflammatory activity of Kandangkathiri Kirutham is evaluated by carrageenan-induced paw edema in rats using Diclofenac sodium as the standard drug. The animals were divided into 4 groups, of which, Group I (Negative control) is injected with carrageenan into the sub-plantar region of the hind paw of rats, Group II & Group III are injected with carrageenan + Kandangkathiri Kirutham (100 mg/kg) & (200 mg/kg) respectively. Group IV is injected with carrageenan + Standard Diclofenac sodium (50 mg/kg). The change in hind paw volume was measured using plethysmometer and expressed as mean paw volume of the rats. The formulation showed significant reduction of paw volume in rats. The results suggest that Kandangkathiri Kirutham has anti-inflammatory activity in rats.

Authors and Affiliations

S. Chitra et al.

Keywords

Related Articles

CHANGES IN TESTIS PROTEIN AND METABOLIC ENZYME ACTIVITIES IN RATS INDUCED BY EPICHLOROHYDRIN

In the present study, an attempt was made to evaluate the changes in testis protein and metabolic enzyme activities induced by epichlorohydrin (ECH), twenty-four albino male rats were divided randomly into four groups of...

GASTRO PROTECTIVE EFFECTS OF USNEA LONGISSIMA METABOLITES ON PROBIOTIC LACTOBACILLUS CASEI

Protective effect of probiotic combination of Usnic acid and Lactobacillus casei in experimentally induced ulcer in rats was investigated. Rats inward Usnic acid (100 mg/kg), L. casei (10-8 con.), Usnic acid (100 mg/kg)...

COSMETIC EVALUATION OF SOME IRANIAN COMMERCIAL NORMAL HAIR SHAMPOOS AND COMPARISION WITH NEW DEVELOPED FORMULATION

Four commercial normal hair shampoos produced by four famous Iranian companies were chosen for evaluating their characteristics based on scientifically measurable properties and were compared with our new developed formu...

PHARMACOGNOSTICAL PHYTOCHEMICAL SCREENING OF ARISTOLOCHIA BRACTEOLATE (ARISTOLOCHIACEAE)

Aristolochia bracteolate is a small glabrous shrub occurring in India. It belongs to the family Aristolochiaceae. The whole plant is used in various ailments like abortifacient, alterative, anthelmintic, antiperiodic, em...

PRILIMINARY PHYTOCHEMICAL SCREENING AND IN-VITRO ANTICONVULSANT ACTIVITY OF METHANOLIC EXTRACT OF LEAVES OF CINNAMOMUM TAMALA (BUCH.-HAM) T. NEES & EBERM (FAMILY- LAURACEAE)

Objective: To perform the phytochemical screening and anticonvulsant activity of methanolic extract of leaves of Cinnamomum tamala (Buch.-Ham) T. Nees & Eberm. Method: The physicochemical parameter and in-vitro anticonvu...

Download PDF file
  • EP ID EP557232
  • DOI -
  • Views 112
  • Downloads 0

How To Cite

S. Chitra et al. (2015). EVALUATION OF ANTI-INFLAMMATORY ACTIVITY OF KANDANGKATHIRI KIRUTHAM IN ANIMAL MODEL. International Journal of Pharmacognosy, 2(11), 543-545. https://www.europub.co.uk/articles/-A-557232