Evaluation of Anti-inflammatory and Antisickling Potentials of Archidium ohioense (Schimp. ex Mull) Extracts
Journal Title: IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS) - Year 2017, Vol 12, Issue 1
Abstract
The study investigated the possible anti-inflammatory and antisickling potential of a moss plant A. ohioense.The phytoconstituents of acetone, chloroform and ethylacetate extracts of the plant were analysed using standard methods. Membrane stabilizing, antisickling, xanthine oxidase and lipooxygenase inhibitory activities of the extracts of the plants on sickle and normal erythrocytes were conducted. Phytochemically, the ethylacetate, acetone and chloroform extracts of A. ohioense showed the presence of cardiac glycoside, flavonoids, saponin, steroid, alkaloids and triterpenes. The acetone and ethyl acetate extracts of the plant stabilized red blood cell membrane of normal and sickle erythrocytes at various concentrations except at 2.0 mg/ml while the chloroform extract exhibits profound protective effect on both normal and sickle erythrocytes at highest concentration used (2.0 mg/ml).All the A. ohioense extracts showed mild anti-lipoxygenase and xanthine oxidase inhibitory activities. As the concentrations of the A. ohioense chloroform and acetone extracts increased, the percentage inhibition of sickling significantly increased and compared favorably with Parahydroxybenzoic acid. These two extracts also demonstrated significant (p ≤ 0.0001) dose dependent increase in antisickling reversal activity. This study indicates that A. ohioense could be valuable source of anti-inflammatory and antisickling agents.
Authors and Affiliations
Akinpelu, Bolajoko Ayinke;, 2 Makinde, Amos Morakinyo, 3Amujoyegbe,Olayinka Olajumoke;, Isa, Musibau Olalekan;, Onwobiko, Victor Chinemerem;, Akinwotu, Akintunde Oluwadare, 2Oladimeji,Ezekiel Seun, Agbedahunsi, 3 JosephMorunfolu;, 1Oyedapo, Oluokun Oluboade
Keywords
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- EP ID EP388196
- DOI 10.9790/3008-1201021826
- Views 86
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