Evaluation of Anti- inflammatory Effect of Pineapple Juice in Rheumatoid arthritis And Osteoarthritis Models in Rats
Journal Title: International Journal of Medical and Health Sciences - Year 2015, Vol 4, Issue 1
Abstract
Background: Arthritis is chronic disabling joint disease. Drugs available produce serious adverse effects on chronic use. Active Ingredient of pineapple fruit (Bromelain) appears promising adjuvant to anti-arthritic drugs. Objective: Evaluation of efficacy of pineapple juice in animal models of rheumatoid arthritis and osteoarthritis. Materials and Methods: First total 48 rats of either sex weighing 250-300 g were divided into 2 batches, (each containing 24 rats), batch I for osteoarthritis and batch II for rheumatoid arthritis . Each batch was subdivided in to 4 groups (n=6). Rheumatoid Arthritis induced by injecting 0.1ml Complete Freund's Adjuvant in sub plantar region of left hind paw. 24 Rats divided into 4 groups (n=6). Group-I: Control, Group-II: Pineapple juice, Group-III: Diclofenac, Group-IV: Pineapple juice + Diclofenac. Oral drug treatment was given from day0 to day12. Paw volume was measured by plethysmometer on day 0, 1, 5, 12, 21. Osteoarthritis induced by intra-articular injection of 50 μl Monosodium-Iodo-Acetate solution. 24 rats divided into 4 groups (n=6) as above and drug treatments given for 14 days. Animals were observed for joint inflammation and gait. On day 15 they were sacrificed, knee joints observed for gross changes and sent for histopathology. Results: Localized inflammatory reaction developed in all rats in 24 hours. In control group, no resolution of swelling, while in others, significant anti-inflammatory activity was seen which was maximum in combination Group-IV, followed by Diclofenac and least with Pineapple juice. Similarly significant anti-inflammatory activity was observed in terms of low histopathology scores in all 3 treatment groups of Osteoarthritis model. Conclusion: Results suggest that Pineapple juice has weak anti- inflammatory activity and can be added as a dietary adjuvant to standard anti-inflammatory drugs.
Authors and Affiliations
Mehwish Majeed, Kanchan Borole
Keywords
Related Articles
- EP ID EP39849
- DOI -
- Views 297
- Downloads 0
Effect of Yogasana and Pranayama on weight, muscle strength and endurance in young Male Medical Students
Introduction: Yoga is well known for its contribution towards maintenance of normal health since Vedic period. Yoga practice has been beneficial in improving muscle power and muscular endurance. Medical students have be...
External Ophthalmomyiasis - A case report
Ophthalmomyiasis is an infestation of the eye with larvae of most common sheep nasal botfly. A 32 year old man who presented with the symptoms of ocular foreign body sensation, redness and excessive tears from his right...
Peripheral Gaint Cell Granuloma- A Rare Case Report With Review of Literature
Peripheral giant cell granuloma (PGCG) is an infrequent red to purple nodular lesion of the oral cavity, also known as giant cell epulis, osteoclastoma, giant cell reparative granuloma, or giant-cell hyperplasia. A 40 y...
Weaning pattern and practices in rural women from wardha district of Maharashtra state
Introduction: Many children in rural communities of developing countries die of nutrition-related causes due to lack of nutrition education and low purchasing power of the families, which result in low-quality weaning f...
Case Report Of Disseminated Staphylococcal Disease In An Adolescent Boy
A 12 year old previously healthy adolescent boy presented with fever, vomiting, pain in the right hip and a limp. Over the next few days he developed pain in multiple joints, arthritis of left knee, osteomyelitis of ri...