Evaluation of Anti-Urolithiatic potential of the Siddha formulation Kalladaippu Chooranam in Ethylene glycol induced urolithiasis in rats
Journal Title: INTERNATIONAL JOURNAL OF CURRENT RESEARCH IN MEDICAL SCIENCES - Year 2018, Vol 4, Issue 9
Abstract
Urolithiasis is the third prevalent disorder of the urinary system. It may cause serious medical consequences such as extreme obstruction, hydronephrosis, infection, and hemorrhage in the urinary tract system. The major drawback of clinical management of renal calculi is its reoccurrence rate. Currently available stone removal techniques like extracorporeal shock wave lithotripsy (ESWL), ureteroscopy (URS), and percutaneous nephrolithotomy (PNL), are considered to be costly, making them an option of choice for limited number of patients. Siddha is one of the ancients medical system in India considered as the mother medicine of ancient Tamils/Dravidians in South India. The word Siddha means established truth or "one who is accomplished" and refers to perfected masters who according to Hindu belief have transcended the ahamkara (ego or Imaker), have subdued their minds to be subservient to their awareness, and have transformed their bodies composed mainly of dense Rajotama gunas into a different kind of bodies dominated by sattva. The main objective of the present research work is to evaluate the anti-urolithiatic potential of the siddha formulation Kalladaippu Chooranam (KC) against ethylene glycol (EG) induced urolithiasis in wistar rats. Induction of urolithiasis in experimental animals carried out by administering ethylene glycol (EG) 0.75% in drinking water for a period of 28 days followed by single dose of sodium oxalate injection (35 mg/kg ,i.p) on 14th day of induction. It was observed from the study that administration of EG in drinking water resulted in increased level of serum calcium, creatinine, uric acid oxalate and phosphate level in the experimental animals. Results on urine investigation reveals similar pattern of increase in urine calcium, creatinine, uric acid oxalate and phosphate. Estimation of urine volume has shown tremendous decrease in urine volume of EG treated rats. Treatment with KC at the dose of 100 and 200 mg/kg shown marked decrease in uric acid, creatinine, oxalate and phosphate level both in serum and urine samples of group II when compare to that of the EG alone treated rats. From the data’s obtained from the present study it was evident that the siddha formulation Kalladaippu Chooranam possesses significant anti- urolithiatic property and may be used for clinical management of renal calculi.
Authors and Affiliations
S. Arulpriya*1 , K. Nithya2 K. Kanakavalli3 , N. Anbu3
Keywords
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- EP ID EP551694
- DOI 10.22192/ijcrms.2018.04.09.005
- Views 161
- Downloads 0
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