Evaluation of Antioxidant and Anti-Inflammatory Activities of Justicia neesii Ramam Whole Plant Extract
Journal Title: JOURNAL OF PHARMACEUTICAL TECHNOLOGY, RESEARCH AND MANAGEMENT - Year 2014, Vol 2, Issue 2
Abstract
The plant Justicia neesii is rich in polyphenolic compounds like lignans which can exhibit anti-inflammatory properties. In this study ethanolic extracts of Justicia neesii was screened for elucidating its antioxidant potential using various methods. In all the methods it has shown good antioxidant nature and reducing ability. The IC50values against DPPH, H2O2, NO and lipid peroxidases were found to be 55.72μg/mL, 133.35μg/mL, 29.65μg/mL and 271.02μg/mL respectively. The total phenolic content in the ethanolic extract was found to be 99.8mg per gram dry plant in gallic acid equivalents. The antiinflammatory nature of Justicia neesii was tested using carrageenan induced paw edema model in rats. The extract has shown significant inhibition of paw volume at all the three gradient doses of the extract. The percent inhibition of paw volume is correlating with the standard diclofinac sodium. From this study we concluded that Justicia neesii is a plant with potent anti-inflammatory molecules.
Authors and Affiliations
Nimakayala Sridhar , Suguna Lakshmi Duggirala , Goverdhan Puchchakayala
Keywords
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- EP ID EP596692
- DOI 10.15415/jptrm.2014.22012
- Views 145
- Downloads 0
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