Evaluation of Cardiovascular Parameters in Acromegalic Patients
Journal Title: Turkish Journal of Endocrinology and Metabolism - Year 2007, Vol 11, Issue 1
Abstract
Both direct action of GH/IGF-1 and secondary cardiovascular risk factors contribute to the development of alterations in cardiac anatomy and function. In the present study we investigated the cardiac involvement in 11 acromegalic patients echocardiographically and compared these measurements with 10 control patients. We also aimed to evaluate the parameters of cardiac structure and function alterations with the duration of disease, blood pressue, plasma GH and IGF-1 levels and HOMA index at the time of diagnosis. Eleven acromegalic patiens with high plasma level of IGF-1 and not suppressible GH level after 75 gr OGTT and 10 healthy controls were enrolled in this study. Insulin sensitivity (IS) was estimated by HOMA index. Cardiovascular parameters were studied with echocardiography using a 2,5-MHZ transducer. Except for aorta root all the structural dimensions of the heart were significantly higher in acromegalic patients than in controls. Left ventricule mass (LVM) index was found significantly higher in acromegalic patients than in controls (z: -1.960 p: 0.050). As a diastolic filling alteration, the rate of mitral early flow velocity (E) to mitral late flow velocity (A) (E/A) was significantly higher in acromegalic patients than in controls (z:-2.446 p: 0.014). No significant correlation was found between LVM index and duration of disease (p: 0.306), blood pressure (p: 0.966 for diastolic blood pressure and p: 0.897 for systolic blood pressure), plasma GH( p: 0.460) and IGF-1 (p: 0.613) levels and HOMA index (p: 0.071). A significant correlation between E/A and systolic blood pressure was observed (r: -0.802 p: 0.017). But no significant correlation was investigated between E/A and the other parameters (for duration of disease p: 0.196, for plasma GH level p: 0.183, for plasma IGF-1 level p: 0.585, for HOMA index p: 0.111). In order to decrease the mortality rate related to cardivascular events, secondary risk factors should be treated beside to normalization of plasma GH/IGF-1 levels. Turk Jem 2007; 11: 1-6
Authors and Affiliations
Hülya Gözü, Derya Öztaş, Yüksel Güleryüzlü, Ömür Volkan, Cihan Dündar, Haluk Sargın, Mehmet Sargın, Ekrem Orbay, Ali Yayla, Cevat Kırmaz
Keywords
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