Evaluation of cutaneous manifestations in patients under treatment with thyroid disease
Journal Title: Turkderm-Turkish Archives of Dermatology and Venereology - Year 2020, Vol 54, Issue 2
Abstract
Background and Design: Thyroid diseases often cause various findings in hair, skin and nails. Some of them may be regressed by the treatment of thyroid disease. We aimed to evaluate the cutaneous manifestations in patients with thyroid disease under treatment. Materials and Methods: This cross-sectional study included 97 consecutive patients with thyroid disease under treatment and 50 healthy controls. Thyroid disease was classiffied as autoimmune and non-autoimmune. All skin findings and dermatological diseases were recorded. Results: Of the patient group, 56 (57.7%) had autoimmune, 41 (43.3%) had non-autoimmune thyroid disease. Eighty-four (86.4%) patients were under thyroid hormone therapy and 13 (23.6%) patients were under anti-thyroid therapy. 73.2% of the autoimmune group, 71.4% of non-autoimmune group and 52% of the control group had at least one cutaneous manifestation (p=0.05). Xerosis (p=0.026), pruritus (p=0.00), facial erythema (p=0.036), flushing (p=0.004), dry hair (p=0.008), brittle nails (p=0.02), dry nails (p=0.013) and longitudinal streaking on nails (p=0.02) were more frequent in the autoimmune group than in the non-autoimmune and control group. Alopecia (p=0.00) was more frequent in the non-autoimmune group. Furthermore diffuse hyperhidrosis (p=0.016), thinning of nails (p=0.059) and rosacea disease (p=0.03) were more common in the patient group than in the control group. At least one cutaneous manifestation, xerosis and various nail findings were more common in patients under thyroid hormone therapy than in patients under anti-thyroid therapy, but there was no statistically significant difference. Conclusion: These findings have shown that various cutaneous manifestations can also be seen in patients with thyroid disease under treatment. We believe that further studies comparing thyroid patients who received and did not receive treatment are necessary to clarify the effect of thyroid disease treatment on cutaneous manifestations.
Authors and Affiliations
Ersoy Acer, Esra Ağaoğlu, Göknur Yorulmaz, Hilal Kaya Erdoğan, Elif Sevil Alagüney, Zeynep Nurhan Saraçoğlu, Muzaffer Bilgin
Keywords
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- EP ID EP685409
- DOI 10.4274/turkderm.galenos.2020.04742
- Views 139
- Downloads 0
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