Evaluation of Diffusion Anisotropy and Diffusion Shape in Grading of Glial Tumors
Journal Title: Journal of Biomedical Physics and Engineering - Year 2019, Vol 9, Issue 4
Abstract
Background: The most common primary tumors of brain are gliomas. Grading of tumor is vital for designing proper treatment plans. The gold standard choice to determine the grade of glial tumor is biopsy which is an invasive method. Objective: In this study, we try to investigate the role of fractional anisotropy (diffusion anisotropy) and linear anisotropy coefficient (its shape) with the aim of Diffusion Tensor imaging (as a non-invasive method) in the grading of gliomas. Methods: A group of 20 patients with histologically glial approved was evaluated. In this study, we used a 1.5-Tesla MR system (AVANTO; Siemens, Germany) with a standard head coil for scanning. Multi-directional diffusion weighted imaging (measured in 12 non-collinear directions) and T1 weighted non-enhanced were performed for all patients. We defined two Regions of Interest (ROIs); white matter adjacent to the tumor and the homologous fiber tracts to the first ROI in the contralateral hemisphere. Results: Linear anisotropy coefficient (CL), fractional anisotropy (FA) values and ratios of low-grade peri-tumoral fiber tracts were higher than high-grade gliomas (Pvalue CLt =0.014, P-value CLt/n=0.019 and P-value FAt =0.006, P-value FAt/n=0.024). In addition, we perform ROC curve for each parameter (CL ratio-AUC = 0.82 and FA ratio-AUC = 0.868). Conclusion: Our findings prove significant difference between diffusion anisotropy (FA) and diffusion shape (Cl) between low grade and high grade glioma, based on which we find this evaluation helpful in the grading of glial tumors. Citation: Davanian F, Faeghi F, Shahzadi S, Farshifar Z. Evaluation of Diffusion Anisotropy and Diffusion Shape in Grading of Glial Tumors. J Biomed Phys Eng. 2019;9(4):459-464. https://doi.org/10.31661/jbpe.v0i0.513.
Authors and Affiliations
F. Faeghi, S. Shahzadi, Z. Farshidfar
Keywords
Related Articles
- EP ID EP648053
- DOI -
- Views 102
- Downloads 0
Why Should We Have a Periodic Safety and Performance Program for Medical Devices
Nowadays, more than 10,000 different types of medical devices can be found in hospitals.These devices used in medical centers and hospitals for monitoring and treatment of patients require periodic safety and performance...
Comparison of Parametric and Nonparametric EEG Feature Extraction Methods in Detection of Pediatric Migraine without Aura
Background: Migraine headache without aura is the most common type of migraine especially among pediatric patients. It has always been a great challenge of migraine diagnosis using quantitative electroencephalography mea...
Analysis of Relative Biological Effectiveness of Proton Beams and Iso-effective Dose Profiles Using Geant4
with proton beams in treatment planning systems (TPS) is of high significance. Given the significance of the issue and the studies conducted in the literature, this quantity is fixed and is taken as equal to 1.1. Objecti...
Dosimetric Evaluation of Volumetric Modulated Arc Therapy (VMAT) and Intensity Modulated Radiotherapy (IMRT) Using AAPM TG 119 Protocol
Background: The commissioning accuracy of Volumetric Modulated Arc Therapy (VMAT) need to be evaluated. Objective: To test and evaluate commissioning accuracy of VMAT based on the TG 119 protocols at local institution. M...
Electromagnetic Fields of Mobile Phone Jammer Exposure on Blood Factors in Rats
Background: The increasing demand for using mobile phones has led to increasing mobile phone jammers as well. On the other hand, reports show that exposure to electromagnetic field causes an increase in the incidence of...