Evaluation of Efficacy, Safety And Tolerability of Transdermal Diclofenac Sodium Patch When Compared To Oral Diclofenac Sodium, For Pain Relief Following Minor Oral Surgical Procedures.
Journal Title: International Journal of Medical Science and Innovative Research (IJMSIR) - Year 2017, Vol 2, Issue 6
Abstract
Aim To compare efficacy, safety and tolerability of transdermal diclofenac sodium patch with oral diclofenac sodium for pain relief. Method 100 participants requiring minor surgical procedures like Bilateral orthodontic premolar extractions, Bilateral surgical removal of third molars, Multiple extractions (U/L first/second molar), Bilateral preprosthetic surgery or any other minor surgical procedures that require staged surgical inervation bilaterally were selected for the study. Surgical procedure on one side was done and oral Diclofenac sodium (75mg SR) b.i.d was given for 3 days. Then after a week, patient was called for the other side surgical procedure. 60 minutes before procedure, Transdermal patch of Diclofenac sodium 200mg (Nupatch) was applied on Trapezius muscle. Then the procedure was done and patient was asked to change patch every 24 hours for the next 2 days. Modified Visual Analogue Scale (VAS) “Faces visual analogue pain scale”, was used to record the pain postoperatively, it is a four point scale, with values from 0-3. Patients were also questioned about adverse effects (Gastro intestinal disturbances, headache, dizziness, allergic reactions erythema, induration, edema). Results and Conclusion Statistical analysis revealed that on Day 1 and 2, study subjects who were taking transdermal diclofenac show mild pain relief whereas subjects who were taking oral diclofenac showed better pain relief for moderate pain and results were found to be statistically significant. (p-value = 0.027, S). On day 3, complete pain relief in the groups who were taking oral diclofenc and there were moderate pain relief who were taking transdermal diclofenac but not statistically significant (p-value=0.208). Also, our results indicate higher tolerability and less adverse effects of transdermal diclofenac patch than oral diclofenac following minor oral surgical procedures. The results indicated that transdermal diclofenac sodium can be used as an alternative form of pain control following minor oral surgical procedures.
Authors and Affiliations
Dr. Mamta Patel
Keywords
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