Evaluation of factors associated with vertical HIV-1 transmission
Journal Title: Jornal de Pediatria - Year 2015, Vol 91, Issue 6
Abstract
Objective To compare the prevalence and factors associated with vertical transmission of human immunodeficiency virus 1 (HIV–1) among pregnant women treated in the periods of 1998–2004 and 2005–2011 in a reference service for the care of HIV-infected patients in southern Brazil. Methods This was a descriptive and analytical study that used the databases of laboratories from the CD4 and STDs/AIDS Viral Load National Laboratory Network of the Brazilian Ministry of Health. HIV-1-infected pregnant women were selected after an active search for clinical information and obstetric and neonatal data from their medical records between the years of 1998 and 2011. Results 102 pregnant women were analyzed between 1998 and 2004 and 251 in the period between 2005 and 2011, totaling 353 children born to pregnant women with HIV-1. It was observed that the vertical transmission rate was 11.8% between 1998 and 2004 and 3.2% between 2005 and 2011 (p<0.001). The increased use of antiretroviral drugs (p=0.02), the decrease in viral load (p<0.001), and time of membrane rupture lower than 4h (p<0.001) were associated with the decrease of vertical transmission factors when comparing the two periods. Conclusion It was observed a decrease in the rate of vertical transmission in recent years. According to the studied variables, is suggested that the risk factors for vertical transmission of HIV-1 were absence of antiretroviral therapy, high viral load in the pregnant women, and membrane rupture time >4h.
Authors and Affiliations
Vanusa da Hora
Keywords
Related Articles
- EP ID EP554531
- DOI 10.1016/j.jped.2014.12.005
- Views 71
- Downloads 0
The road to eliminate mother-to-child HIV transmission
The World Health Organization's Global Health Observatory estimates that 78 million people have been infected with the human immunodeficiency virus (HIV) during the course of the epidemic, and that 39 million men, women,...
Association between postpartum depression and the practice of exclusive breastfeeding in the first three months of life
Objective To investigate the association between postpartum depression and the occurrence of exclusive breastfeeding. Method This is a cross-sectional study conducted in the states of the Northeast region, during the va...
The association between healthy lifestyle behaviors and health-related quality of life among adolescents
Objective The aim of this research was to examine the association between body mass index, physical activity, adherence to the Mediterranean diet, and health-related quality of life in a sample of Spanish adolescents. M...
Serum levels of melatonin may contribute to the pathogenesis of heart failure in children with median age of 1 year
Objective Melatonin has a protective role in adults with cardiovascular disease, but the effects of melatonin in children with cardiac dysfunction are not well understood. This study was designed to explore the variation...
The Brazilian Portuguese version of the Pediatric Trigger Toolkit is applicable to measure the occurrence of adverse drug events in Brazilian pediatric inpatients
Objective To describe the process of translation, adaptation, and validation of the Brazilian Portuguese version of the Pediatric Trigger Toolkit: Measuring Adverse Drug Events in the Children's Hospital. Methods The va...