Evaluation of gastro protective activity of Fish Oil (Omega- 3 Fatty Acids) against experimentally induced acute gastric ulceration in Rats
Journal Title: International Journal of Medical and Health Sciences - Year 2012, Vol 1, Issue 2
Abstract
Fish oils contain the omega-3-fatty acids eicosapentaenoic acid and docosahexaenoic acid precursors of certain eicosanoids that are known to have a wide range of clinical use. The present study was conducted to evaluate the anti ulcer activity of fish oil in HCl-ethanol induced acute ulcer model. The animals were divided into five groups with six rats in each group. Ranitidine (30mg/kg/orally) used as a standard and Fish oil 5% v/w and 10% v/w used as a test-I & II, other group was administered normal diet for 30days. On the 31st day ulcers was induced by administration of HCl and then stomach was removed from rats observed under magnified lance to count ulcer index. 10% v/w and ranitidine pretreated groups showed significant gastro protective activity compared with HCl treated group. In the physical observation of HCl treated gastric mucosa showed extensive lesions compared with other groups. The above study observations proved Fish oil (omega-3-fatty acids) have antiulcer activity but there is requirement of further pre-clinical and clinical studies to support and increase the use of fish oil in the treatment of various pathological conditions.
Authors and Affiliations
Divakar. V, Sylvia Shanthakumar, Sarath Babu. K, Devika. T
Keywords
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