Evaluation of gastroprotective efficacy of ethanolic extract of Curcuma amada rhizomes in rats
Journal Title: International Journal of Research in Pharmacology & Pharmacotherapeutics (IJRPP) - Year 2016, Vol 5, Issue 1
Abstract
The objective of this study was to investigate the gastroprotective efficacy of rhizomes of Curcuma amada (mango ginger, Ambahaldi), Zingiberaceae in rats. The antiulcer activity of ethanolic extract was evaluated in Indomethacin, ethanol induced gastric ulcer model & stress ulcer by cold water immersion method in wistar rats. The rhizome extracts were prepared by a successive solvent extraction process with petroleum ether, chloroform, ethanol & water. Phytochemical analysis & acute oral toxicity were carried out using standard methods. The preliminary phytochemical screening of Curcuma amada revealed the presence of resins, tannins & flavanoids etc. The Ethanolic extract at a concentration of 200mg/kg & 400 mg/kg exhibit a protective effect on ulcer induced models & was compared with standard drugs Ranitidine, Misoprostol, Omeprazole. Percentage ulcer inhibition of Ethanolic extract at 400 mg/kg for Indomethacin, ethanol & stress induced ulcer model were 39.31%, 40 % & 35 % respectively. Among the doses studied ethanolic extract 400 mg/kg body weight was found to be optimum for significant reduction in ulcer. The flavanoids present in the Ethanolic extract might be responsible for the gastroprotective action probably by maintaining the antioxidant level in the gastrointestinal tract thereby reducing mucosal damage. The extract exhibit ulcer protection activity in dose dependent manner.
Authors and Affiliations
Kumar Sumit
Keywords
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