EVALUATION OF HEPATOPROTECTIVE ACTIVITY OF TECTONA GRANDIS LINN.
Journal Title: International Journal of Pharmaceutical and Medicinal Reserach - Year 2014, Vol 2, Issue 3
Abstract
Hepatic damage is associated with distortation of the metabolic functions of liver. Thus liver diseases remain as the serious health problems. The present study was aimed to evaluate the hepatoprotective activity of hydroalcoholic extract of Tectona grandis leaf. The phytochemical screening showed the presence of alkaloids, amino acids, carbohydrates, flavonoids, saponins, steroids, triterpenoids, and tannins. Evaluation of hepatoprotective activity of hydroalcoholic extract of Tectona grandis leaf was carried out at two dose levels 300 mg/Kg and 600 mg/Kg. Carbon tetra chloride induced hepatotoxic model was followed for investigation of hepatoprotective activity of Tectona grandis in wistar rats. The biochemical parameters (SGOT, SGPT and ALP) in rat serum were found to be increased in CCl4 induced hepatotoxicity model. Hydroalcoholic extract of Tectona grandis leaf was found to decrease the biochemical parameters (SGOT, SGPT and ALP) of rat serum at the doses of 300 mg/Kg and 600mg/Kg. Hydroalcoholic extract of Tectona grandis leaf significantly (p≤0.05) and dose dependently produced hepatoprotective activity at the doses of 300 mg/Kg and 600 mg/Kg.
Authors and Affiliations
Kapil Sachan, Pranjal Kr. Singh, Vrish Dhwaj Ashwlayan, Ranjit Singh
Keywords
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