EVALUATION OF IN VITRO ANTI-OXIDANT AND ANTI-ARTHRITIC ACTIVITY OF METHANOLIC EXTRACT OF MARINE GREEN ALGAE CAULERPA RACEMOSA
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2015, Vol 7, Issue 7
Abstract
Objective: The present study was aimed to evaluate in vitro anti-oxidant activity and in vitro anti arthritic activity of methanolic extract of Caulerpa racemosa.Methods: The in vitro anti oxidant activity was evaluated by using following method viz; DPPH scavenging activity, Nitric oxide scavenging activity, Total anti-oxidant activity, Determination of reducing power. The in vitro anti arthritic activity was evaluated by using protein denaturation method.Results: Methanolic extract of Caulerpa racemosa showed a very good anti-radical activity in scavenging DPPH radical and nitric oxide radical with maximum % inhibition of 88.87±1.05% at 2000μg/0.1 ml concentration and 80.49±1.43% at 2000μg/ml respectively. Total anti-oxidant activity and reducing power of Caulerpa racemosa was found to be 32μg equivalents of ascorbic acid at 500 μg/ml and 88.80±0.98% at 2000μg/0.05 ml respectively. The methanolic extract showed 49.33±0.597% of percentage inhibition at 1000μg/0.05 ml by protein denaturation method.Conclusion: From the results obtained, it can be concluded that the methanolic extract of Caulerpa racemosa possesses significant anti-oxidant and anti-arthritic activity. Further studies are required to signify the mechanism of action of these pharmacological activities and to mark them out for their significant pharmacological actions.Â
Authors and Affiliations
Sumanya H, Lavanya R, Umamaheswara Reddy C
Keywords
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