Evaluation of Nootropic activity of Two Marketed Drugs of Bacopa monnieri In Scopolamine Induced Amnesic Models
Journal Title: Indian Journal of Research in Pharmacy and Biotechnology - Year 2018, Vol 6, Issue 2
Abstract
Evaluation of Nootropic activity of Two Marketed Drugs of Bacopa Monnieri In Scopolamine Induced Amnesic Models. The Learning and memory parameters were evaluated by using Morris water maze and Passive avoidance model in Swiss albino mice. The two marketed products of Bacapa monnieri was administered at a dose of 100 mg/kg body weight orally for 14 days to the respective groups. Piracetam (400mg/kg,i.p.) was used as a standard nootropic agent. It was observed that two products of B.monniere at the above-mentioned dose after 14 days of administration in the respective groups significantly reversed scopolamine (40mg/kg i.p.) induced amnesia, as evidence by a decrease in the acquisition and retension phases were in the and step down latency in the passive avoidance task. In this study brand 2 shown significant response when compare to brand-1, may be due to reduction in the brain ChE activity in mice may prove to be a useful memory restorative agent in the treatment of dementia seen in Alzheimer’s disease.
Authors and Affiliations
D. V Kishore, R Sridhar Babu, Arshiya Begum, Amatun Noor, Saba Farheen, Syeda Maimoona Kauser, Ahmed Abdul Majid Yaser
Keywords
Related Articles
- EP ID EP33512
- DOI -
- Views 312
- Downloads 0
Carbon nano materials
Nanomaterials and nano particles are usually considered to be materials with at least one external dimension. Nanomaterials internal structures measuring 100 nm or less. Form these particles prepared by tubes, rods or...
COMPARISION OF POTENCY OF ANTI BACTERIAL ACTIVITY AND ANTI INFLAMMATORY ACTIVITY OF 10 YEARS AND 100 YEARS OLD BARK EXTRACTS OF AZADIRACHTA INDICA
Azadirachta indica (Meliaceae) commonly known as neem contains many biologically active compounds including alkaloids, flavonoids, triterpenoids, phenolic compounds, Carotenoids, steroids and ketones, azadirachtin. Oil...
REVIEW ARTICLE ON ANTIMICROBIAL RESISTANCE
Antimicrobial resistance (AMR) is not a recent phenomenon, but it is a critical health issue today. Over several decades, to varying degrees, bacteria causing common infections have developed resistance to each new ant...
Formulation and Evaluation of Irbesartan Microspheres
In the present work, microspheres of Irbesartan using sodium alginate as a retarding polymer were formulated to deliver Irbesartan via oral route. The results of this investigation indicate that solvent evaporation met...
Effect of soaking pits on the quality of Ground water
Ground water purity is very important in human’s health. The present paper has shown the effect of soaking pits on the ground water. Fluoride is commonly present in the ground water. But due to soaking pits the quality...