Evaluation of Oxidative Stress and Antioxidant Status in Patients with Type 2 Diabetes Mellitus and its Correlation with Glycosylated Hemoglobin
Journal Title: International Journal of Medical and Health Sciences - Year 2015, Vol 4, Issue 1
Abstract
Aim: To evaluate serum Total Antioxidant Capacity(TAC) and serum Total Peroxidase (TP) Oxidative Stress Index (OSI) and measure its correlation with Glycosylated Hemoglobin (GHM). Study design: an analytical case control study. Place and Duration of study: Department of Biochemistry, School of health and allied science, Pokhara University, between November 2012 and February 2013. Methodology: The study encompassed of 110 subjects who were distributed into two groups, 55 Type 2 Diabetic Mellitus (T2DM) and 55 healthy controls, relying on serum Fasting Blood Sugar (FBS), Post Prandial Blood Sugar (PPBS) clinical history and medication. Serum values of TAC and TP were measured; OSI was calculated and correlated with GHM. Biochemical markers (serum urea, creatinine, protein, albumin and bilirubin) were also determined in all study subjects. Results: The results showed non-significant differences in two groups with respect to age, body mass index and blood pressure (all p>0.05).Serum level of FBS, PPBS, GHB and MBG (mean blood glucose) were significantly higher in T2DM subjects (p > 0.05). Spearman’s correlation analysis in the T2DM subjects showed a statistical significant and positive correlation of FBS with OSI, PPBS with TP and GHB with OSI, TP but negative correlation of GHB with TAC and that of TP and OSI with total protein and total bilirubin while non-significant correlation with urea, and creatinine. Conclusion:T2DM subjects showed higher level of TP and OSI index and lower level of TAC with regard of decreased individual antioxidant - total protein, albumin, uric acid and total bilirubin.
Authors and Affiliations
Niraj Chaudhary,Nidhi Sharma Chapagain,Rabindra Kumar Baral,Sanjog Timilsina,Surendra Tiwari
Keywords
Related Articles
- EP ID EP39838
- DOI -
- Views 330
- Downloads 0
Effect of Pharmacological treatment on cardiac biomarkers in patients with acute coronary syndrome of non–ST segment elevation with Type-2 diabetes
Background: The acute coronary syndrome is a consequence of coronary artery disease. Creatine Kinase MB is a cardiac biochemical marker used in the diagnosis and risk stratification of patients. The diabetes is a pathol...
Sexual Dimorphism in Hand and Foot Dimensions in Chhattisgarh Region
Introduction: Relationship between different body parts especially the limbs is being used to establish sex and stature. which is a prerequisite to identification in forensic investigation Ascertaining sex and estimatio...
Prevalence of Urban Geriatric Depression - A Cross sectional Study in Pondicherry
Background: Geriatric depression is an important public health problem. There is a dearth of community studies from India investigating geriatric depression and its associated risk factors. This study aimed to establis...
Chiropractic Care of Postlaminectomy Syndrome: A Report of 2 Cases
Herein, the author presents two cases where chiropractic techniques appear to have been successful in alleviating postlaminectomy syndrome (PLS). PLS is a condition characterized by persistent back pain or leg pain after...
An Unusual Case of Acute Puerperal Uterine Inversion : A Case Report and Review of Literature
Acute uterine inversion is a rare potentially life threatening obstetric emergency. It can present either in the puerperal (obstetric) or non-puerperal (gynaecological) setting. The immediate risk to the patient is due...