Evaluation of Performance of the Newly Developed de Cordova's Formula for Calculation of Low-Density Lipoprotein Cholesterol without Use of Triglycerides
Journal Title: Journal of Enam Meical College - Year 2014, Vol 4, Issue 1
Abstract
Background: Various formulas are available to estimate serum low-density lipoprotein (LDL) cholesterol. All of these are serum triglycerides (TG) dependent. But very recently de Cordova et al developed a simple formula (CF) to calculate LDL cholesterol without using serum TG and claimed it to be more accurate than Friedewald.s formula (FF). Objective: The objective of the present study was to evaluate the performance of the CF for the calculation of LDL cholesterol in a Bangladeshi population. Materials and Methods: Three hundred and sixty adult Bangladeshi subjects were purposively included in this study. Serum total cholesterol (TC), TG, high-density lipoprotein (HDL) cholesterol and LDL cholesterol were measured by direct automated methods. LDL cholesterol was also calculated by CF and FF. Results were expressed in conventional unit as mean ± SD and compared by two-tailed paired t test, bias against measured LDL cholesterol, Pearson's correlation coefficient (r), Passing & Bablok regression and accuracy within ±10% of the measured LDL cholesterol. Results: The mean values of directly measured LDL cholesterol, LDL cholesterol calculated by CF and FF were 117.7 ± 31.0, 111.8 ± 31.0 and 108.9 ± 39.7 mg/dL respectively. Bias of calculated LDL cholesterol against measured LDL cholesterol was -5.2% for CF and -9.6% for FF. The correlation coefficients of measured LDL cholesterol were 0.9796 (p<0.001) for CF and 0.9525 (p<0.001) for FF. Passing & Bablok regression yielded the equation y = 0.9938x - 6.2 for CF and y = 1.2774x - 40.9 for FF. Accuracy within ±10% of measured LDL cholesterol was 81% for CF and 49% for FF. Conclusion: This study revealed better performance of the de Cordova's formula than Friedewald's formula for approximate calculation of LDL cholesterol without using serum triglycerides.
Authors and Affiliations
Abdul Hai Siddique, Muhammad Saiedullah, Nasreen Chowdhury, Md Aminul Haque Khan
Keywords
Related Articles
- EP ID EP36181
- DOI https://doi.org/10.3329/jemc.v4i1.18062
- Views 348
- Downloads 0
A Case of Childhood Ovarian Teratoma
Germ cell tumors are malignant (cancerous) or nonmalignant (benign, noncancerous) tumors that are comprised mostly of germ cells, the cells that develop in the embryo and become the cells that make up the reproductive...
Acute Retrograde Jejunogastric Intussusception
A 65-year-old male was admitted into Enam Medical College Hospital through emergency unit with severe upper abdominal colicky pain, paroxysms of haematemesis and constipation for one day. He had undergone gastric sur...
Urinary Tract Infection and Drug Susceptibility Pattern in Patients of a Medical College Hospital in Bangladesh
Background: Urinary tract infection (UTI) is a common and frequently encountered serious morbidity that afflicts the tool not only to all segments of human population but also results in increasing antibiotic resistanc...
Study of Forced Expiratory Volume in First Second (FEV1) and Ratio of Forced Expiratory Volume in First Second and Forced Vital Capacity in Percentage (FEV1/FVC%) in Pregnant Women
Background: A few data are available on the effects of pregnancy on pulmonary function in different countries. But no such established data are available in our country. So we designed this study in our population. Obj...
https://www.banglajol.info/index.php/JEMC/article/view/27766/18497
Nipah virus, a member of the genus Henipavirus, a new class of virus in the Paramyxoviridae family, has drawn attention as an emerging zoonotic virus in South-East and South Asian region. Case fatality rate of Nipah vi...