Evaluation of Proteinuria in Normotensive Diabetics in a Tertiary Care Hospital
Journal Title: Journal of Medical Science And clinical Research - Year 2018, Vol 6, Issue 8
Abstract
Background: Proteinuria has been generally regarded as a marked for the degree of glomerular damage in diabetes. The levels of proteinuria correlate well with the progression for renal functions and interventions that retard the progression of diabetes renal disease also reduce proteinuria. The aim of this study is to collate information on the incidence of proteinuria among normotensive diabetic patients attending Hi-tech Medical College and Hospital, Rourkela, Odisha Materials and Methods: The study involved 100 diabetics and 50 healthy controls. Proteinuria was estimated using biuret method, while fasting blood glucose using glucose oxidase method. Result: The study shows that an overall 22% of the patients have diabetes related proteinuria with 17% males and 5% females. The duration of the disease < 5 years (42.0%) and > 5 years (58.0%) have 14.5% and 31.1% diabetes related proteinuria respectively. An average age of < 30 years (30%) and > 30 years (70%) have diabetes related proteinuria of (17.1%) and (24.6%) respectively. FBG differed significantly (p<0.05) between patients (11.01±1.03Mmol/L) and controls (4.38±0.07Mmol/L). Urinary protein excretion was significantly higher in diabetics (143.7±5.78) than in controls (90.43±5.78). Increased urinary protein excretion was observed (p<0.05) with duration of diagnosis <5 years (228±5.4mg/24hrs) and >5 years (264±9.1mg/24hrs). Statistically significant increase in proteinuria (p<0.05) was also observed in males (254±10.0mg/24hrs) than in females (194±29mg/24hrs). Conclusion: Given the large number of individual with diabetes is increasing; the number of diabetic nephropathy is undoubtedly enormous. This could produce major constraints on health care budgets in the future. This urgently calls for not only good control of diabetes to prevent nephropathy but also to address the larger issue of primary prevention of diabetes, that is, reduction in the prevalence of diabetes itself by aggressive life style modifications
Authors and Affiliations
Dr Brijesh Mukherjee
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