Evaluation of Red Blood Cell Indices in Patients of Falciparum Malaria
Journal Title: Journal of Indus Medical College - Year 2019, Vol 2, Issue 1
Abstract
OBJECTIVE: The aim of this study was to examine red cell indices seen at the Tertiary Care Hospital, in order to determine their usefulness in diagnosing falciparum malaria. PATIENTS AND METHODS: This was a case control study. The study was performed from February 2018 to September 2018 at the Department of Pathology, Indus Medical College Tando Muhammad Khan. One hundred and ninety-six children aged 6 months to 40 years were recruited into the study including 98 diagnosed with malaria and 98 controls. The control subjects were recruited as no clinical features of malaria. Hematocrit (HCT), haemoglobin concentration (HB), mean corpuscular volume (MCV), mean corpuscular haemoglobin (MCH) and mean corpuscular haemoglobin concentration (MCHC) were the following red cell indices obtained from the samples. The data was analysed using version 21.0 of SPSS. By measuring sensitivities, specificities, positive predictive and negative predictive values, the diagnostic precision was calculated. The accuracy of these statistics was tested using a confidence interval of 95%. RESULTS: The HCT had a 80.04% sensitivity and an 82.15% specificity, while the HB had an 82.87 sensitivity and a 72.01 specificity. The positive predictive values for HCT and HB were respectively 88.76%, and 87.91%. Low values were found in MCV (57.91%), MCH (0%), and MCHC (0%). However, there was a important association between MCH and MCHC with malaria (P<001). CONCLUSION: The occurrence of anaemia would be a valuable supporting criterion in the diagnosis of malaria.
Authors and Affiliations
Shahzad Ali Jiskani, Inayatullah Memon, Umair Ali Soomro, Shumail Siddiqui, Mehnaz Shaikh, Huma Abbasi
Keywords
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