Evaluation of response and toxicity of paclitaxel and carboplatin combined with intensity-modulated radiotherapy for upper esophageal carcinoma
Journal Title: Medpulse International Journal of Radiology - Year 2018, Vol 6, Issue 3
Abstract
Purpose: This study was conducted to evaluate the effectiveness and safety of intensity-modulated radiotherapy (IMRT) and concurrent paclitaxel plus carboplatin (TP regimen) for upper esophageal carcinoma. Methods: 40 patients of upper esophageal carcinoma were retrospectively analyzed. Patients were treated with IMRT (median 60 Gy) combined with concurrent TP regimen chemotherapy. The Kaplan-Meier analysis was performed in statistical analysis. Toxicities were recorded according to the NCI CTC version 4.0. Results: 40 patients aged 35–70 years (median 53 years). The median follow-up period was 14.0 months. The 1-year and 2-year survival rates were 83.3% and 42.8% respectively. The median progression-free survival (PFS) time and overall survival (OS) time were 12.0 (95% CI: 7.8–16.2 months) and 18.0 months (95% CI: 9.9–26.1 months), respectively. Grade 3 neutropenia, radiation-induced esophagitis and radiodermatitis were observed in 6 (15%), 7 (17.5%) and 8 (20%) patients respectively. There were two treatment-related deaths due to esophageal perforation and haemorrhage. Conclusions: For those patients with upper esophageal carcinoma, IMRT combined with concurrent TP regimen chemotherapy was an effective treatment. However, more attention should be paid to the occurrence of perforation and haemorrhage.
Authors and Affiliations
Punita Pant, Jitendra Patel, B K Shewalkar
Keywords
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- EP ID EP533573
- DOI 10.26611/10136312
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