Evaluation of serum vitamin D levels in patients with lichen planus
Journal Title: Turkderm-Turkish Archives of Dermatology and Venereology - Year 2020, Vol 54, Issue 4
Abstract
Background and Design: Lichen planus (LP) is a chronic inflammatory disease of unknown etiology that most commonly affects the skin and oral mucosa. Vitamin D is a steroid hormone with immunomodulatory, anti-inflammatory and antioxidant effects. The purpose of this study was to evaluate serum vitamin D levels in patients with LP and to compare these with those of healthy control subjects. Materials and Methods: Forty-eight patients with a diagnosis of LP and 46 healthy controls were enrolled in the study. The serum levels of 25-hydroxy vitamin D, calcium, phosphate and parathyroid hormone were studied from blood samples collected from all subjects. Results: The serum levels of vitamin D were lower in the LP patients compared to the controls and in the oral erosive LP patients compared to the other LP patients, although the difference was not statistically significant. There were no statistically significant differences in other laboratory parameters between the patient and the control groups. Conclusion: Our study revealed no clear relation between LP and vitamin D levels. The results of our study suggest that other factors except vitamin D, particularly probable triggers, play a more dominant role in the immunopathogenesis of LP. Further studies with larger patient populations assessing serum vitamin D levels in different types of LP and vitamin D-related gene polymorphisms are now needed in order to reveal the relation between LP and Vitamin D more clearly.
Authors and Affiliations
Deniz Aksu Arıca, Leyla Baykal Selçuk, Asım Örem*, Zeynep Karaca Ural, Savaş Yaylı, Sevgi Bahadır
Keywords
Related Articles
- EP ID EP691624
- DOI 10.4274/turkderm.galenos.2020.66664
- Views 136
- Downloads 0
A challenging diagnosis on dermoscopy: Lichen Planus Pigmentosus
No summary
Ibrutinib-associated hematoma and ecchymosis in a patient with basal cell carcinoma who underwent Mohs micrographic surgery
Basal cell carcinoma (BCC) is the most common skin cancer. The gold standard therapy is surgery in the treatment of BCC. The recomended surgical method is Mohs micrographic surgery, as it provides the highest cure rates...
Two cases with lichen planus pigmentosus inversus accompanying ankylosing spondylitis and diabetes mellitus
Lichen planus pigmentosus (LPP) is an inflammatory dermatosis with an unknown etiology characterized by dark brown-black macules, papules and patches. LPP is considered as a rare variant of lichen planus (LP), but it dif...
The correlation of age, gender and drug dose with side effects of isotretinoin in patients with acne vulgaris
Background and Design: Acne vulgaris is a chronic inflammatory disease of pilosebaceous unit. Oral isotretinoin is the most effective agent that has been used for many years in acne treatment. The purpose of our study wa...
The use of an urticaria control test for the evaluation of omalizumab treatment response in patients diagnosed with chronic urticaria
Background and Design: Urticaria is a very common skin disease which is characterized by itchy, erythematous and edematous plaques. Angioedema can also be seen in half of the cases in addition to skin findings. In most c...